Here is what I got back on ENMD:
Judah Folkman is a highly respected researcher and some people said that he "has solved the cancer problem" when his findings were first announced. I don't know much about what happened subsequently except that as of today the cancer problem is not yet solved. So I suspect it isn't as big an advance as first believed. I don't know anything at all about Entremed but I believe they already had a big run-up after the initial announcements. Without spending a lot of time to look into this, that's about all I know about it. The basic idea is that Cancer Cells have to be supplied with a lot of new blood supply (angiogenesis) and if some way could be found to block this (anti-angiogenesis) then the Cells would not grow.
That was his take.....below is more information than you would ever want to know on ENMD
wolff
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This post is a good place to start your "Basic Research" into EntreMed to specifically share information on the 'astonishing' science called ANGIOGENESIS. Other drugs are ahead but NOTHING has shown what the endogenous -- naturally in us -- proteins like Endostatin and Angiostatin have shown in animal models. Dr. Moses Judah Folkman is the "Father of Angiogenesis" and Dr. Michael O'Reilly discovered endostatin and angiostatin. EntreMed is "The Angiogenesis Company."
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SECTION I: GENERAL OVERVIEW: "WHY ALL THE EXCITEMENT?"
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a) Hemoncdoc's famous 5 lessons: A MUST READ, especially the first lesson.
ragingbull.com
b) Compilation of Audio/Video presentations:
ragingbull.com
c) A tremendous compiliation that explains the history of angiogenesis:
moffitt.usf.edu
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SECTION II: "ENDOSTATIN: THE HUMAN TRIALS"
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a) PHASE I TRIALS WELL UNDERWAY at all three clinics (week 17 at Dana Farber, with the highest dose starting this week - 240mg):
1) DANA FARBER - Boston, MA.(w/Dr. Folkman)
The hot line number is 617-632-5100
o- Dana Farber says they will update this site with the latest ES Trials news:
cancercare.harvard.edu
o- More from Dana Farber: (Note the quote from Ms. Sundeen on toxicity giving endostatin to primates: "up to 300 times what you would give a human, and there was still no toxicity."
intelihealth.com
2)Trials have started in MD Anderson - Houston
mdanderson.org
3) Trials started this week at the UofW Madison, for updated information, go here:
cancer.wisc.edu
uw150.wisc.edu
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SECTION III: "ANGIOSTATIN: THE HUMAN TRIALS"
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February Update: **IND Approved!
If you have been following the story, you would probably think angiostatin was a drug that has already been given its last rites. True if you work for Bristol-Myers, however ENMD resuscitated rhuAngiostatin(R) easily and now it is headed into humans soon at Thomas Jefferson University Hospital in Philadelphia:
entremed.com
a) Read some Press Releases on Angiostatin from EntreMed:
entremed.com
entremed.com
entremed.com
b) Note what a little Angiostatin does when combined with Radiation:
egroups.com
c) What about KRINGLE 5 of Angiostatin?:
egroups.com
d) Did you see what happened to a teen treated already with an Angiostatin approach?
ragingbull.com
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SECTION IV: "2ME2: THE HUMAN TRIALS"
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February Update: **IND Approved!
2ME2 goes after the tumor and blood
compartments, pill form, small molecule, 'formulated and made' for upcoming Phase I trials.
entremed.com
2-Methoxyestradiol (Apotopin):
ragingbull.com
Various abstracts:
egroups.com
.....("Bye..bye...Taxol and BMY.")
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SECTION V: DR. MOSES JUDAH FOLKMAN
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a) Learn all you can on Dr. MOSES JUDAH FOLKMAN "The Founding Father of Angiogenesis."THE ANGIOGENESIS SCIENCE IS SOUND, go listen to the audio/video presentations:
ragingbull.com
b) Learn all you can about Dr. Folkman, a recap:
egroups.com
c) Do your own search on endostatin or angiostatin and then compare them to ANY Chemo, MoAb (labeled or unlabeled), Gene Therapy, Apoptosis, Telomerase, Chemo, vaccines, or any other specific endogenous angiogenesis inhibitor.
ncbi.nlm.nih.gov
d) Why is Thalidomide,"Proof Of Principle" important?
(...and remember EntreMed gets royalties from every sale.)
egroups.com
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SECTION VI: MOUSE TO MAN
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1) Read Hemoncdoc's lesson number three.
ragingbull.com
2) Read this one from Internist_MD:
ragingbull.com
3) Some of us think naturally in us endostatin already works. How does autopsy data and being able to measure levels of endostatin in us point to this? Also, you can BUY human or murine Endostatin and do your own testing. If you don't believe Dr. Folkman or EntreMed, see for yourself, thousands of mice are waiting to die of old age thanks to endostatin.
ragingbull.com
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SECTION VII: "THE COMPETITION"
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a) OTHER ANGIOGENESIS INHIBITORS
Other angiogenic inhibitors are WAY AHEAD. Ahead yes, BUT Angiostatin/Endostatin/Apotopin (and GZMO's aaaATIII) are the only SPECIFIC anti-endothelial cell/anti-BLOOD SUPPLY closest to trials. Keep an eye on companies claiming they now have endogenous anti-angiogenic therapies more potent -- a pharmacological term for "you need less, not works better than"-- than the now new benchmark rhuEndostatin(TM). Endostatin is already the benchmark. Keep in mind, Dr. Bjorn Olsen, August 1999, published to have used 2000 times LESS Endostatin in his 'striking' experiments where he made HUMAN endostatin in kidneys. Also, another group found with TNP-470 by using a pump it was 15 times more potent. They are expecting to test Endostatin this way as well, maybe in phase I even?
b) ALL OTHER INHIBITORS
o- Go to the NCI's site that lists them all with phone numbers:
cancertrials.nci.nih.gov
o- We try to keep track of ALL inhibitors. Check them all out:
egroups.com
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SECTION VIII: "CONFUSION?"
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CONFUSED ON....
a)PATENTS? Note USA patent 5,854,205 Must read!!!
Go here:
uspto.gov
Do a PATENT NUMBER search on:
5,854,205 "Therapeutic antiangiogenic compositions and methods "
b)...large molecule, hard to make, ship, duplicate results? HUH? These are NOT issues for HUMAN versions of the proteins.
entremed.com
c)....endostatin working in Leukemia, a blood cancer?
(As stated in the Dr. Folkman section, they haven't found a tumor they can't regress, including leukemia, all this is on tape at the NIH. Papers on leukemia/lymphoma still waiting to be published....these guys take forever.)
They have found LEUKEMIA is intensely 'angiogenic' when they stained the bone marrow, read here:
egroups.com
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SECTION IX: "THE MEDIA: THE GREAT, THE BAD, AND THE WORST STREET JOURNAL"
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Unfortunately, a few in the media have really messed up this unbelievable breaking story. This section shows the difference. What many don't understand is Gina Kolata's accurate May, 1998, NYTs article was about the fifth article following the 'stunning' Nature article in November, 1997. Here is what Wm.Boot, our media EXPERT writes in general about the media:
ragingbull.com
Specific to the WSJ:
ragingbull.com
Another excellent summation of what has happened:
February 26, 1999: Science "Behind the Headlines of Endostatin's Ups and Downs":
egroups.com
a) "THE ARTICLES"
Check out the articles and notice the dates, many tremendous articles. Please pay special attention to Richard Saltus at the Boston Globe and John Crewdson at the Chicago Tribune:
ragingbull.com
b) COMPARE AND CONTRAST THESE TO THE WSJ's UGLY SPIN BY Ralph 'Burger' King (5 times now) and 'deputy' Waldholz.
ragingbull.com
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SECTION X: THE NATIONAL CANCER INSTITUTE
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The NCI has made tremendous progress with helping EntreMed get endostatin into patients. Unfortunately, the NCI was recently in the cross hairs of the terrible WSJ hack reporting. Did you see how the NCI fought back to the WSJ? 9-15-99
nih.gov
THE WSJ ACTUALLY RAN A CORRECTION
ragingbull.com
TRIALS WILL NOT TAKE YEARS (thanks Eye8MadCow)
Do you still think it takes an average of 6-8 years to get drugs through trials? We don't. Did you see how the NCI "significantly restructered" the Clinical Trials just in time for rhuEndostatin(TM)?
cancertrials.nci.nih.gov
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SECTION XI: HEART DISEASE AND OTHER
ANGIOGENIC DEPENDENT DISEASES
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Just how big is it? 500 Million in US and Europe alone?
detnews.com
Angiogenesis is a HUGE emerging science.
Also, EntreMed has signed up a contract with Moulton's work on Endo-DRANO-statin, potentially huge benefits:
ragingbull.com
The collaboration:
entremed.com
Further, check out this press release from Stanford, note what the first guy who ever performed an angioplasty on a patient has to say about ANGIOGENESIS in cardiology:
"Four distinguished physicians in the field of cardiology will discuss this new form of treatment(angiogenesis), one of the most significant advances in coronary artery disease therapy since angioplasty."
egroups.com
Also, note this section on Endostatin from the US Patent Office:
"It is yet another object of the present invention to provide a method and composition for treating diseases and processes that are mediated by angiogenesis including, but not limited to, hemangioma, solid tumors, leukemia, metastasis, telangiectasia psoriasis scleroderma, pyogenic granuloma, myocardial angiogenesis, plaque neovascularization, corornay collaterals, cerebral collaterals, arteriovenous malformations, ischemic limb angiogenesis, corneal diseases, rubeosis, neovascular glaucoma, diabetic retinopathy, retrolental fibroplasia, arthritis, diabetic neovascularization, macular degeneration, wound healing, peptic ulcer, fractures, keloids, vasculogenesis, hematopoiesis, ovulation, menstruation, and placentation."
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SECTION XII: ENTREMED - "THE ANGIOGENESIS COMPANY"
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a) On EntreMed, everything we post is accurate. If you doubt it, please talk to Ms. Mary P. Sundeen, Senior Director, Corporate Communications & Investor Relations at: (301) 738-2490
b) Check out their INFORMATIVE website:
entremed.com (note FAQ section on Endostatin)
c) Get to know the genius of CEO/Founder, Dr. John Holaday:
ragingbull.com
Have your own opinions on EntreMed management? Don't forget to check these out from Lelongtemps and JJFlash:
ragingbull.com
ragingbull.com
d) Look at all ENMD's press releases:
entremed.com
-or- (A good URL for AS/ES Abstracts - thanks George)
lef.org
e) Year End Conference Call (Highlights ramping up Phase II for rhuEndostatin, stock BUY BACK from BMY)
-o Go listen to the year end conference call and pay attention to the important details, from 12/13/99:
entremed.com
Keep going Drs. Folkman, O'Reilly, D'Amato, Boehm, Browder, Olsen!...GO Dr. Holaday and all the EntreMed employees, thank you from the bottom of our hearts for this huge glimmer of REAL hope in a REAL fight against cancer.
GO DANA FARBER, UNIVERSITY OF WISCONSIN MADISON, and MD ANDERSON IN HOUSTON! HOUSTON NEEDS THE MOST HELP, THEY ARE EIGHT MONTHS BEHIND!
"Lethality is ANGIOGENESIS dependent." (Folkman, Dec. 1999)
Yours In a REVOLUTION on CANCER,
-The FolkMANIACS
A few of our MOTTOS:
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"STARVE THE TUMOR, SAVE THE PATIENT"
"NO BLOOD, NO GROWTH, NO FUTURE!!"
"LONG on the SCIENCE;SHORT on CANCER!"
Special warning for the short sellers of ENMD:
Anchor Post = "Writing on the wall."
People are DYING at 1500+ A DAY (one Titanic or 3 full 747s of our family members and friends) in the "good Ol' USA," our own backyards. ENOUGH DEATH! Hear that Congress?
abcnews.go.com
The "War on Cancer" was signed on December 23, 1971!! Billions spent; millions dead. Dr. Folkman's first paper on angiogenesis was FINALLY accepted in 1971 and accurately predicted where we are today. Here is proof why the entire Medical Industry needs to do some of its own soul searching:
ragingbull.com |
