To: Anthony@Pacific who wrote (54260 ) 4/6/2000 10:56:00 AM From: Tassi Read Replies (1) | Respond to of 122087
SCLN...Good news.. This should rock " should we say "$21" NewsWire ZADAXIN Plus Chemotherapy Shows Promise for Improved Survival in Advanced Skin Cancer -------------------------------------------------------------------------------- Skin Cancer Phase 2 Results Published in Melanoma Research SAN MATEO, Calif., April 6 /PRNewswire/ -- SciClone Pharmaceuticals (Nasdaq: SCLN) announced today that a study published in the peer-reviewed journal Melanoma Research (Volume 10, Issue 2, April 2000) suggests that ZADAXIN(R), SciClone's lead immunotherapy, increases the effectiveness of chemotherapy for metastatic malignant melanoma, the deadliest form of skin cancer and one of the most rapidly increasing types of cancer worldwide. In the open label pilot Phase 2 study of 20 stage III-IV metastatic malignant melanoma patients, there was a response rate of 50% to the combination therapy of ZADAXIN, dacarbazine (DTIC) and interferon. Five patients showed a complete response and 5 showed a partial response. Median survival among all patients was 11.5 months, with 5 patients having survived for more than 2 years, and 2 patients having survived for more than 5 years. No additional side effects or toxicities were observed from the inclusion of ZADAXIN. DTIC therapy significantly depresses a patient's immune system. In the study, ZADAXIN significantly improved the patients' immune system by restoring their natural killer (NK) cells and helper T-cells (CD4), both of which are disease fighting white blood cells. "We believe ZADAXIN immunotherapy will be a key component of multiple drug treatments for numerous cancers, infectious diseases and immune system disorders," said Donald R. Sellers, SciClone's President and Chief Executive Officer. "This study, in addition to a prior pilot phase 2 metastatic malignant melanoma study, several preclinical cancer studies, recent mechanism of action studies and our long experience in treating hepatitis patients, all validate that belief. We expect malignant melanoma to be a major focus of our new U.S. cancer program." No proven life-prolonging therapy exists for metastatic malignant melanoma, the leading cause of skin cancer death. Approximately 44,000 new cases are diagnosed each year in the U.S. and 7,300 deaths are reported. The response rate with the current drug of choice, DTIC, is approximately 20% and is usually of short duration with little impact on survival. Many patients with cancer and chronic infectious diseases have an impaired immune system. ZADAXIN significantly enhances the immune system's ability to recognize and destroy cancerous and infected cells. ZADAXIN may be a key component in the growing trend toward multiple drug cocktails for cancer and infectious diseases. ZADAXIN immunotherapy is in late-stage development for cancer and viral hepatitis worldwide. ZADAXIN now is approved for marketing in 19 countries, principally for treatment of hepatitis B and hepatitis C. SciClone has filed for ZADAXIN marketing approval in 18 additional countries. SciClone Pharmaceuticals is a global specialty pharmaceutical company that develops and commercializes novel medicines for treating a broad range of the world's most serious diseases. The Company has focused its current product development and commercialization activities on cancer, hepatitis B, hepatitis C, drug-resistant tuberculosis and cystic fibrosis. Press releases and corporate information from SciClone Pharmaceuticals are available on the Internet at www.sciclone.com or by calling the Company's Investor Relations Department at 800-724-2566. SciClone's Common Stock is listed on The Nasdaq National Market(R) under the symbol SCLN. The information in this press release includes certain forward-looking statements concerning the Company's current expectations regarding future events, including the ongoing and prospective development and commercialization of ZADAXIN immunotherapy for cancer, including metastatic malignant melanoma in the U.S., and the timing of the start and potential for success of the Company's U.S. phase 2 studies for metastatic malignant melanoma. Due to market factors and the nature of product development and the regulatory approval process, the forward-looking statements contained in this press release are subject to risks and uncertainties, including those reflected in the Company's filings with the Securities and Exchange Commission. SOURCE SciClone Pharmaceuticals -0- 04/06/2000 /CONTACT: Shawn K. Singh, J.D., Chief Business Officer, 650-358-1451, or Ruth Koh, Investor Relations, 650-358-3437, both of SciClone Pharmaceuticals/ /Company News On-Call: prnewswire.com or fax, 800-758-5804, ext. 775865/ /Web site: sciclone.com (SCLN) CO: SciClone Pharmaceuticals ST: California IN: MTC PUB SU: JD-JJ -- SFTH023 -- 0647 04/06/2000 09:30 EDT prnewswire.com