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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Cacaito who wrote (13918)	7/1/2000 10:17:43 PM
From: Bluegreen	Respond to of 17367

Cacaito, you need to concentrate on the words PROTECTIVE AND ANTIBACTERIAL. MAYBE you need to look up the word SYNERGY also. In my opinion IF Neuprex is approved EVERYONE that receives IV antibiotic for ANY gram neg infection will also get IV Neuprex. OF COURSE I MIGHT BE WRONG BUT BAXTER CLAIMS possible uses and revenues if approved IN EXCESS OF 500 Million bucks. It is MY investment decision. ALL Biotechs are risky and of course I could lose ALL my money BUT I am going along with Allergan Baxter and Genentech. What else can I say? I think from now on most of my posting will be done on the Genentech, Allergan and Baxter boards. Look forward to your posts on those boards. Doesn't make sense to post here since deals made to those companies and the ball is in their court and they are responsible for moving Neuprex and anti-Cd11a forward for the most part. Once again I was thrilled to see you doing so well in this Biotech market. Hopefully things will work out the same for us long time Xoma holders. FOR NOW............BASTA YA!!!!!!!!! BASTA YA!!!!!!!!!!

To: Cacaito who wrote (13918)	7/2/2000 7:31:40 AM
From: Robert K.	Read Replies (1) \| Respond to of 17367

Cacaito. First let me say right off congrats on your call and second you "can be" a excellent poster when you want to be. What I see is a almost hatred for xoma and a anti-xoma bia's. When you want you can have very interesting thoughts and opinions as some recent notes reveal. Because of your tone, I question your objectivity though. Again, I congradulate you on you lilly call but dont make the mistake that lilly has won. They may win a sepsis drug or they may not. The battle is not over, although I am sure the market calls it as a lilly victory party. So you can properly or improperly assume that lilly will be the first to market a sepsis drug as the market has assumed. All eyes are on lilly for sure, no doubt there. I remember way back when Antril (anti-il-1) was a sure thing too. I say this to you. you can probably expect the unexpected and the unexpected is always the biggest surprise/event. I do not know how events will play out, but I bet things will get even more interesting. No facts really, just IMO as usual. Standard K

To: Cacaito who wrote (13918)	7/2/2000 10:47:02 AM
From: aknahow	Read Replies (1) \| Respond to of 17367

Cacaito, I don't believe I haver tried to put words in your mouth, or insist you were saying something other than what you really meant. Perhaps you misunderstand me. 1. I am not saying Neuprex worked in the Trauma trial. The trial failed. I am saying the trial did not prove Neuprex does not work, IF the 50% reduction of incidents in the placebo group is true. 2. I am not saying XOMA is involved in any way in the production of LLY's Protein C. I am saying XOMA owes us a yes or no because LLY has a license to the cell expression technology and it was obtained considerably before LLY to its product into clinic. 3. I am not saying failure is better than success but only that given the many regulatory hurdles and past failures, (SCIOS even had a positive recommendation from the FDA committee), I am surprised at anyone canting victory before the battle is actually won.

To: Cacaito who wrote (13918)	7/2/2000 1:20:50 PM
From: Bluegreen	Read Replies (1) \| Respond to of 17367

Cacaito, WHAT AFFECT DOES NEUPREX HAVE ON HEPARIN????? It has been said that Neuprex might mop up endotoxin BUT what role as anti-inflammatory???? My opinion is that SYNERGY as an antibiotic is key. More RAPID and EFFECTIVE killing of GRAM NEG BUGS!!! But it has to be given IMMEDIATELY in order to have maximal effects. As far as cost.....NOT AN ISSUE. Just look at how many livers and kidneys are destroyed or damaged by administration of antibiotics for gram neg infections. Not to mention emergence of resistant bugs. Who is willing to take a chance when you have a safe addition to use???? Maybe even able to lower dosages of conventional antibiotics in gram neg infections and avert toxic dosages that are damaging to kidneys and livers not to mention hearing and eyesight damage. Once again I feel very confident in my investment now that we are mainly at this point in the hands of ALLERGAN, BAXTER and of course bigshot GENENTECH!!!!! Funny that the company you hate was picked by GENENTECH for anti-CD11a!!!! Unlike you who am I to second guess GENENTECH????? Only my opinions. You might want to think about this>>>>>>>>>>>>>>>Gut 2000 Jul;47(1):88-96 Related Articles, Books, LinkOut Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism. Salas A, Sans M, Soriano A, Reverter JC, Anderson DC, Pique JM, Panes J Gastroenterology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain. BACKGROUND: In addition to its anticoagulant properties, heparin has anti-inflammatory effects, the molecular and mechanistic bases of which are incompletely defined. AIMS: The current studies were designed to test the hypothesis that heparin abrogates the expression or function of leucocyte-endothelial adherence molecules which are fundamental to the acute inflammatory response. METHODS: The effects of heparin on tumour necrosis factor alpha (TNF-alpha) induced leucocyte rolling, adhesion, and migration as well as vascular permeability were assessed in rat mesenteric venules using intravital microscopy. Expression of adhesion molecules was quantitated using a double radiolabelled monoclonal antibody (mAb) binding technique in vivo (P-selectin, intercellular cell adhesion molecule type 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1)) or flow cytometry (CD11a, CD11b, and L-selectin). Ex vivo binding of heparin to neutrophils was assessed by flow cytometry. RESULTS: TNF-alpha induced a significant increase in leucocyte rolling, adhesion, and migration, and vascular permeability, coincident with a significant increase in expression of P-selectin, ICAM-1, and VCAM-1. Ex vivo assessment of blood neutrophils showed significant upregulation of CD11a and CD11b and significant downregulation of L-selectin within five hours of TNF-alpha administration. Heparin pretreatment significantly attenuated leucocyte rolling, adhesion, and migration but did not affect expression of cell adhesion molecules or vascular permeability elicited by TNF-alpha administration. Binding of heparin was significantly increased on blood neutrophils obtained five hours after TNF-alpha administration. Preincubation with an anti-CD11b mAb but not with an anti-CD11a or anti-L-selectin antibody significantly diminished heparin binding ex vivo. CONCLUSIONS: Our results support the concept that the anti-inflammatory effects of heparin involve attenuation of a CD11b dependent adherent mechanism.<<<<<<<<<<<<<

To: Cacaito who wrote (13918)	7/2/2000 1:40:00 PM
From: Bluegreen	Respond to of 17367

CACAITO, from the Baboon study>>>>>>>>>>>>Bacteremia was significantly reduced in the rBPI21 group at 2 hours after the start of the E. coli infusion, whereas circulating LPS was less affected.<<<<<< I can't state it any better. AT TWO HOURS!!!!!! CAN YOU IMAGINE THAT????? AT TWO HOURS!!!!!! CAN YOU SAY RAPID AND EFFECTIVE ANTIBACTERIAL ACTION??? Gram neg bugs don't stand much of a chance when you poke holes in them. Now how is it possible that BACTEREMIA was SIGNIFICANTLY reduced?????? Was it SYNERGY?????? IS IT SAFE??????? IS BAXTER INVOLVED????? WHY????? WHY DID ALLERGAN EXPAND THEIR DEAL WITH XOMA?????? BTW, in the past HOW RAPIDLY DID XOMA GO FROM 2 A SHARE TO 16?????LOL