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To: axial who wrote (8321)	12/30/2001 9:21:18 AM
From: twentyfirstcenturyfox	Read Replies (1) \| Respond to of 14101

Hi Gang: Can we play dumb and dumber? my dumber question is, can Pennsaids be used to alleviate tendinitis? My wife (shewhoisnotgonnakillmeaaaneeeemooore) has recently been diagnosed with tendinitis in her heels. I want those heels in good enough shape for her to kick them up, on the occasion of this company achieving its next milestone (OT: since this is a Canuck company - how come its not meterstone or kilometerstone or - hey, Dimestone?). Which would then lead us to the adoption of a corporate 'anthem' : i'm a dimestone cowboy). Fox.

To: axial who wrote (8321)	12/30/2001 10:03:03 AM
From: Mark Bartlett	Read Replies (1) \| Respond to of 14101

Jim, No problem and no need to apologize for the questions. BTW, my grandfather was a carpenter ... far from dumb. <<- To what "adherence" does this refer? Adherence to a therapeutic regime? >> Yes -- they are referring to sticking to the pill regime. Typically AIDS patients have had to take a mountain of various pills each day and compliance has been reported to be poor. Today the regime is less, although still considerable. WF10 is given in cycles over several weeks. Once this is completed, the WF10 part of the regime is done -- so except for this TX period, WF10 will not add to the ongoing TX burden. <<The question is, IYO, can you see WF10 being "fine-tuned" (and improved) as it is better understood?>> Potentially. Understanding how something works is important but not always necessary for it to be approved. There are many drugs whose mode of action is not fully understood. My sense with WF10, is it will just be a question of how well it works in certain applications (cancers, MS, Hepatitis C etc and other autoimmune illnesses) and in combination with other TX modalities. <<I'm trying to understand why WF10 would not be used as an adjunct to all viral infections>> Not all viral infections will necessarily lead to the chronic, long-term pro-inflammatory state that is characteristic of HIV and hepatitis C (and other autoimmune diseases). With these diseases, it is clear that this chronic long-term inflammation leads to the pathological state that damages the body (whether it be the immune system or the liver). Certain infections and autoimmune diseases appear to hinder the body's ability to down-regulate this pro-inflammatory state -- likely for several reasons. For most infections, this pro-inflammatory response is good and needed during the acute stage of the infection. However when the acute stage of the infection is over, the pro-inflammatory response must be down-regulated back to a normal "background" level to avoid damage to the body. <<Finally, IYO, is it possible that the specific mechanism underlying WF10's success so far is still undiscovered>> Over the last couple of years there has been considerable progress in understanding how WF10 works. If you go to Oxo Chemie's site and go to the presentations of Dr. Michael McGrath, there is a 5 part series that describes the research. I'd drop in the URL but it did not connect for me as I wrote this. This is the Coles notes version -- hope it helps. MB

To: axial who wrote (8321)	1/2/2002 4:18:55 PM
From: Mark Bartlett	Read Replies (3) \| Respond to of 14101

Jim, Further to your question, go to the Oxo site at: oxochemie.com Hit the "Research Programs Button" and go to the section that starts: The Immune System Scroll down to the last paragraph (one sentence) that reads: "A schematic of the immune system in infectious diseases and the postulated effects of WF10 are shown on our video presentation here. " 'Here' is a hyperlink that take you to a 5 part video presentation that details the proposed mechanism of action of WF10. Enjoy! MB