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Gold/Mining/Energy : Nuvo Research Inc -- Ignore unavailable to you. Want to Upgrade?

To: Mark Bartlett who wrote (8500)	1/25/2002 1:35:01 AM
From: russet	Read Replies (1) \| Respond to of 14101

How does the DMSO-NSAID complex get through the epidermis? Perhaps through the pores, but at some point it must cross a cell membrane. The cellular transport system you speak of,...perhaps the intracellular transport system, is inside the cell. DMSO must somehow dissolve through the outer epidermis passing through cell membranes of cells in the inner epidermis to get to a cell that has that intracellular network of tubules to be able to travel from cell to cell and eventually get to the nerve cells in the irritated inflamed tissue around the joints and deaden the pain. It also has to drag the Nsaid with it. Given DMSO has polar and non-polar ends, it may form a liposome and sort of dissolve into the membrane, something like endocytosis,...or perhaps there is some kind of passive or active transport mechanism utilizing cell membrane proteins. Got any papers on that mechanism, especially how it penetrates through the outer epidermis? If DMSO can drag the NSAID, it is probable it can drag other molecules as well,...perfume, soaps, whatever that may be on the skin. Some may not be tolerated that well causing irritation at the site of application and encouraging the patient to stop use. Irritated skin gets holes in it,...source of infection and further irritation. Chronic pain will require chronic applications of Pennsaid. Many years of such use could cause many skin problems at the site of application, which would not show up in the current short term uses which are in the medical databases. Do you know of any long term use data? As you say, irritation would cause the patient to stop use. Chronic use may increase the frequency and types of irritation beyond the current 5% you sight. I too agree here, and in a previous post, that a little irritation may be preferable to what oral NSAIDS eventually due to liver, stomach, kidneys. Unfortunately the big money and ease of use sides with the pills at present. Perhaps intermittent, non overlapping use of both is the answer, to allow the irritated organs to recover while still allowing continuous pain relief.