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Biotech / Medical : RNAi -- Ignore unavailable to you. Want to Upgrade?

To: tuck who wrote (261)	7/27/2004 4:32:38 PM
From: Ian@SI	Read Replies (2) \| Respond to of 671

Referenced article makes me wonder if we'll see any substantial RNA silencing treatments within the next decade... eurekalert.org Researchers look into components of RNA silencing machinery ...

To: tuck who wrote (261)	8/11/2004 7:41:49 AM
From: Thomas	Read Replies (1) \| Respond to of 671

Off topic: targeting tumors with nanotechnology. Sounds pretty interesting (thanks to Jeff Harrow). Cheers, Thomas theharrowgroup.com Cancer Killer? I suspect that what may turn out to be the most significant benefits of nanotechnology will be in the medical fields. Speculation is rife about tiny robots that will be injected into the bloodstream to wander around performing specific tasks, such as "Rotor Rooting" clogged arteries, and perhaps even performing surgery while you go about your normal routine. But sometimes, especially at the beginning, "simpler" can be better, as demonstrated by what seem to be incredible results from Jennifer West, professor of bioengineering and chemical engineering, and her team -- they're using specially built gold nanospheres to kill cancer tumors, apparently with 100% success! As published in pages 171 - 176 of Issue 2 of the June 25 Cancer Letters (an abstract is freely available while the full text requires a subscription), and summarized in a June 21, 2004 Rice University press release, the researchers created silica spheres 20-times smaller than a blood cell and then added a surface layer of gold. One characteristic of these spheres is that, depending on their size and the ratio of silica to gold, they can be "tuned" to respond to particular wavelengths of light. In this case they're sensitive to near-infrared light, which passes through normal tissue without hindrance and without causing damage. Once injected into the veins of test mice that all had significant cancer tumors, the researchers waited six hours for the nanospheres to circulate through the body. Because of a characteristic of cancer tumors, that their internal blood vessels are poorly formed and tend to leak fluid into the surrounding tissue (the tumor), the gold nanospheres tended to collect within the tumors. Then, the researchers applied a near-infrared laser to the skin over the tumor areas. Although the healthy tissue was not affected, the nanospheres became quite hot as they absorbed the near-infrared light, raising the temperature in the tumor tissue by "around 50-degrees C". And the tumors were destroyed. (When the laser was applied to areas that did not have nanosphere-holding tumors below them, there was virtually no temperature change.) Within ten days, the nanosphere-treated group of mice was cancer-free and continued to live a normal lifespan! On the other hand, the tumors in two control groups (one receiving only saline injections plus the near-infrared light, and another group receiving no treatment), continued to grow "rapidly," causing the mice in these two groups to die in 10 to 12 days respectively. These are, of course, only preliminary studies, and apparently on only one type of tumor. But the results are both dramatic and startling - a non-invasive cancer treatment with 100% effectiveness and no apparent side-effects! Think of the implications if and when such a treatment becomes commonly available and effective across the spectrum of cancer tumors -- a major source of human pain and death could itself be put to death.