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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?


To: Biomaven who wrote (13163)9/28/2004 2:38:24 PM
From: Michael Young  Read Replies (3) | Respond to of 52153
 
How are we supposed to take AGIX's results seriously when they only evaluated 133 out of 500 trial subjects?



To: Biomaven who wrote (13163)9/28/2004 2:57:50 PM
From: bio_kruncher  Read Replies (1) | Respond to of 52153
 
re: NABI
we can make educated guesses and calculate some probable p-values.
68 pts / 4 trt groups= about 17 per group.
ways to get 33% are : 5/15, 6/18, 7/21
ways to get 9% are: 1/11, 2/22 (this seems odd)
Chi-square pvalues range from 0.328 to 0.114
I don;t think the 2/22 is a likely outcome for placebo so i'd quess p-value is in the 0.2 - 0.3 range.

OF concern would be lack of disclosure of 'quit rate' for lower dose groups and no mention of antibody results(which was the objective of the study). Interesting results but i think the study is just too small to choose a dose for smoking cessation. Larger Phase II dose ranging still needed.



To: Biomaven who wrote (13163)9/29/2004 8:25:36 AM
From: SnowShredder  Read Replies (1) | Respond to of 52153
 
Hi Peter,

re NABI

fwiw...When I was in grad school, in one class we talked about the catalytic Ab for Cocaine. My professor mentioned how some people who were treated used larger doses of coke since they weren't getting the same effect from their normal dose. I wonder if the same will happen with smokers who take the vaccine?

<bwdik?>

Best of Luck,

SS