To: Stephen O who wrote (8650 ) 11/22/2004 10:03:17 PM From: Casaubon Read Replies (1) | Respond to of 9523 You have a preconceived notion about my opinions because of your biased slant against big pharma. I never claimed big pharma was altruistic. They are a business and must make a profit to remain in the game. They provide a valuable service and do tremendous good for the benefit of human suffering but, it comes at a price. You have chosen to take an excerpt of that article which appeals to your bias against big pharma. The real point of the article, however, was to posit the notion that all drugs have inherant risks . That does not make them bad drugs, nor does it make big pharma evil or immoral. The article is trying to enlighten people about the general dual edged nature of medicine. There is some risk, which is supposed to be greatly outweighed by some benefit. Also, as I've mentioned before, the article points out that clinical trials can not identify all side effects. Only the most common events are identified in a trial. When a drug is administered to a larger population many more side effects are discovered, including drug-drug interactions, which are not often encountered in a clinical setting. Do mistakes happen? Of course. Are drug companies acting in a malicious manner? Of course not. That article explains how Merck came to be aware of increased heart risk, of VIOXX, through an appropriately designed clinical trial. As a result of the properly controlled clinical trial, Merck made the ethical and morally correct decision to voluntarily withdraw the drug from the market. Even if suspicions were raised previously that such a risk might exist, the only proper course of action is a well designed (and expensive) clinical trial. In other words, Merck had to put their own necks in the noose. They had to shoulder the burden of expense to demonstrate that their own multi-billion dollar drug needed to be removed from the market. When confronted with the very real possibility of increased heart risk, that is exactly what Merck did. They paid for an expensive, massive clinical trial which demonstrated the need to remove there own drug! That is not the action of an immoral company! We need to move away from the litiginous mindset which has become a plague of modern society. Now there are people actually sueing Merck to reinstate VIOXX into the market, according to that article. How can the pharmaceutical companies win? All I'm trying to do is place some sanity into the motives and occurances surrounding the pharmaceutical industry. It's a very tough game and great progress has been made, by the pharmaceutical industry, which has directly contributed to longevity and ease of suffering of human beings. Even greater progress is yet to come.