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Pastimes : Let's Talk About Our Feelings!!! -- Ignore unavailable to you. Want to Upgrade?


To: Grainne who wrote (91304)12/14/2004 8:40:45 AM
From: Oeconomicus  Read Replies (2) | Respond to of 108807
 
Keep weaseling. It's a slur and you know it. Look, personally I don't care if you want to run around screaming "fascists" at everyone who disagrees with you - that just makes you look like a fool. But you're the one making such a big deal out of your "feelies" no name-calling policies and banning Dithers for a perceived slight against some unnamed persons not even posting on this thread, even after he clarified what he wrote to make it clear he wasn't directing at anyone here. Your behavior is hypocritical.



To: Grainne who wrote (91304)12/14/2004 6:35:22 PM
From: epicure  Read Replies (1) | Respond to of 108807
 
I found this article fascinating. It just goes to show how much damage you can do, to a lot of people, when you rush to judgment, and can't keep your mouth shut about your rush...

washingtonpost.com
Libel Suit Takes Aim at Print Reporter's Words on TV

By Alicia Mundy
Special to The Washington Post
Tuesday, December 14, 2004; Page A01

The phone rang shortly after 6 a.m. on Feb. 13, 2002, at Superior Judge Ernest B. Murphy's home in Dover, Mass., southwest of Boston. His wife, Mary Keenan, answered. "Have you turned on the news this morning?" a friend asked her. "Do you know what's in the Herald?"

The friend told her that a large photo of her husband was on the front page of the Boston Herald under the headline "Murphy's law: Lenient judge frees dangerous criminals." The story said Murphy "heartlessly demeaned victims" and had dismissed the trauma of a 14-year-old rape victim by saying, "Tell her to get over it."

Keenan woke her husband, who, as she tells it, was stunned. He told his wife he never said that.

The report was quickly picked up by news media nationwide, then worldwide. It became fodder for TV talk shows. Massachusetts politicians and the victim's mother called for Murphy's ouster.

In June of that year, Murphy filed suit against the Herald and four of its writers for a "malicious and relentless campaign of libel unprecedented in the history of this Commonwealth." In court papers, he said the Herald "set out to sensationalize" a story that never happened. As a result, he said, his life had been threatened, his reputation had been ruined, and two of his daughters had been threatened with rape on a Herald-sponsored chat room. In August of this year, a Boston judge refused to dismiss the lawsuit.

The case, set for trial next month, is significant because it uses the rambunctious exchange on a talk show to try to prove the malicious intent of a newspaper reporter.

The brief cites statements made by a Herald writer not just in the pages of the tabloid but also on Fox News's "The O'Reilly Factor." A videotape of the show was played in court during a key hearing.

The case "reflects the perils of this new media culture" in which reporters go on the air to promote their stories, said Tom Rosenstiel, director of the Project for Excellence in Journalism. While editors scrutinize and sanitize reporters' words before they appear in print, no one performs that function in live TV interviews.

"When reporters who write stories, then go on the air to discuss" them, said Lucy Dalglish, executive director for the Reporters Committee for Freedom of the Press, "things tend to escalate. . . . If their appearances are going to be used to craft evidence of malice and reckless disregard for the truth in a print story, we're in very dangerous territory. I think this will have very serious implications for journalists."

Kurt Wimmer, a specialist in First Amendment law at Covington & Burling in Washington, pointed out that a television appearance by a reporter after a story appears in print extends the time allowed to show a reporter's state of mind and "raises another category of issues to bring against a newspaper or television station." He added: "The era of the reporter-celebrity may be coming to an end."
A Media Campaign

New Bedford, Mass., the Bristol County seat, is an old whaling town, best known as the port where Captain Ahab set off after Moby Dick and the place where an infamous pool hall rape occurred in the 1980s. By 2002, other controversies were swirling. County prosecutors were suing the Massachusetts Superior Court for refusing to give them more judges. And they were complaining about one judge they thought was too lenient: Murphy. Then 59, he had been on the bench for two years. Both a staunch Republican and a recovering alcoholic, he has said in court that "he believes in redemption," according to the Boston Globe.

The New Bedford Standard Times reported on Feb. 9, 2002, that one assistant district attorney called Murphy "the worst person in a black robe I have ever seen."

The comment appeared two days after Murphy had sentenced Dean McSweeney, then 18, for two counts of statutory rape the previous summer and for an unrelated robbery of a convenience store at knifepoint. The rape victim was the 14-year-old sister of McSweeney's best friend, Jimmy Taylor.

Taylor's mother, Teri Taylor, had taken McSweeney in when he became estranged from his family. According to affidavits, McSweeney, who was 17 at the time, stayed at the home frequently, had spent several hours in the girl's bedroom with her and twice took advantage of her.

"When I found out about this two weeks later from my daughter, I drove her straight to the Mansfield police station and filed a complaint," Teri Taylor said. "I told the cops to go pick up McSweeney."

The prosecutor had hoped to put McSweeney in prison for five years -- for the robbery. The charges against him already had been reduced to statutory rape because no force was involved. Even the prosecutor said Murphy wanted to give McSweeney some prison time, maybe a couple of years. But sentencing guidelines allowed a choice only between a full five years for the charge of "masked" robbery, or no prison time at all.

In court, Murphy said: "I myself have five daughters. . . . I understand what a daughter is. . . . I'm not oblivious to these considerations. . . . [But] I know what happens in state's prison when people like Mr. McSweeney show up at 17 years old."

Murphy sentenced McSweeney to eight years' probation.

Prosecutors were incensed and ratcheted up their media campaign. On Feb. 11, the Boston Globe ran a story under the headline "Bristol DA slams judge's bail rulings."

Herald reporter Dave Wedge, too, had received a tip about Murphy's "lenient" record a couple of weeks earlier, according to his deposition. But now two other local papers had run stories, which his editor "pointed out." Wedge quickly spoke with a Bristol district attorney who was a frequent source, according to his deposition.

On Feb. 13, a week after McSweeney was sentenced, the Herald published Wedge's "Murphy's Law" story, saying prosecutors had "confronted" the judge in his chambers over his sentences. At that time, Murphy allegedly said of McSweeney's victim, "Tell her to get over it."
Story Takes Its Toll

Two days later, the Murphy family, including daughters Jessica, 14, and Emily, 10, left for their annual school break vacation at a time share in the Caribbean. "We thought things would blow over," Murphy's wife said.

Instead, they escalated. In the end, the Herald printed 17 stories and columns involving Murphy. Teri Taylor held a news conference with her daughter, the victim, in her back yard and demanded that the judge be fired. She requested an investigation by the Commission on Judicial Conduct. (She said she was later informed that Murphy had been cleared.)

Meanwhile, on WEEI-AM, Herald sports columnist Gerry Callahan, co-host of "Dennis & Callahan," began referring to Murphy as "Easy Ernie" on the popular morning radio show, Murphy's lawyers said. Callahan has not returned phone calls seeking comment.

In St. Maarten, Murphy received a call from his daughter Adrienne. She read him a column in the Feb. 20 Herald by Howie Carr titled "Easy Ernie judges daughter's teasing to be out of order." She faxed him pages from Carr's follow-up Internet chat.

"If there were real justice in this world the 'poor rapist' would go to Easy Ernie's house and rape all of HIS daughters twice," said one. Another typed: "Publish his street address and then tell him to 'get over it.' He's a public employee and the public has the right to know!" And one reader volunteered: "Easy Ernie doesn't reside in Sherborn. Reliable info has him residing in neighboring Dover."

"That was it for me," said Keenan, Murphy's wife. Jessica and Emily were sent back home, where they found police guarding their house. They collected some clothes and schoolbooks. Under police escort, Emily went to stay with their grandmother in Quincy, and Jessica bunked with one of her friends. The girls were told only that too many reporters were hanging around. But reading the newspaper, Jessica learned about the threats. "My mom and dad cried when they told me what was really going on," she said.

The next week, Teri Taylor appeared on "The O'Reilly Factor." Host Bill O'Reilly promised her, "We're going to stay on this story and hopefully we'll get the Massachusetts politicians involved and get this guy, Murphy, off the bench." Meanwhile, Greta Van Susteren of Fox News told her "On the Record" audience, "Judge Murphy advised the girl, 'Get over it.' While she ponders the judge's callous advice, maybe Massachusetts should ponder this: Get rid of him."

Bristol County chief prosecutor Paul F. Walsh Jr., in his deposition, called the public uproar a "frenzy" and said: "It went farther than I could comprehend."

As the stories continued, Murphy's daughters had their own crises. In an interview, Jessica said she "really freaked out." She gained weight, and her grades dropped. She couldn't sleep in her bedroom on the first floor, for fear of someone breaking in. "I cried all the time, I had terrible dreams," she said. "I stopped leaving my house."

Emily also started having crying jags and refusing to go out, Jessica said. Her mother said she had nightmares about men suffocating her.

Back in his office, Murphy found piles of hate mail. A Californian who had seen O'Reilly wrote angrily that he had canceled his vacation in Massachusetts. A woman in Derby, England, asked him to overturn the "deplorable sentence." Another woman told him to do the "decent" thing and "step down." Rape counselors excoriated him.

One enterprising correspondent sent him a piece of toilet paper wrapped around a wad of excrement. "You piece of [expletive]," it said. "I'm going to wipe you out."

Murphy developed post-traumatic stress disorder and later collapsed with a large duodenal ulcer near an artery. "The aftermath has quite literally torn my guts out," he said in his lawsuit. He asked the court to assign him to hear only civil cases. The blustery Irishman began breaking down in tears -- sometimes in front of lawyers, Jessica said.

One day, Murphy found an anonymous envelope in his chambers. In it was a copy of his picture from the Herald, with a bull's-eye drawn around his face and the words "You're dead. Get over it, You bastard."

Murphy bought a Magnum.
Searching for Truth

It took three weeks before Murphy fought back in print. When the Herald had asked him to comment, the day after Wedge's "Murphy's Law" story ran, he declined, citing rules on closed judicial discussions. But when a Boston Globe reporter called him in early March 2002, when the case was closed, he talked.

"I deny that I ever said anything critical of, or demeaning about, the victim," he said. "Every single quote that has been attributed to me about that has been fabricated out of thin air. The real truth is 180 degrees. I was extremely concerned about the welfare of the victim, and I made that position apparent to everyone."

Indeed, the prosecutor, David E. Frank, said in a sworn affidavit that during the only conference related to McSweeney's sentencing: "Murphy expressed concern for the victim. He asked counsel about the defendant's ability to pay for counseling for the victim." He added: "I never heard Justice Murphy say 'Tell her to get over it.' "

So where did the quote come from?

According to the deposition of David Crowley, an assistant prosecutor, Murphy mentioned the case in an unrecorded conference relating to a different case the day after the McSweeney sentencing. The judge allegedly said that the victim "is 14; she can't go through life as a victim. She's got to get over it." Crowley reported this to his boss, Gerald Fitzgerald, in the prosecutor's office, and Fitzgerald then asked Crowley to meet with the Herald reporter.

"She's got to get over it' or "Tell her to get over it" -- two different sentiments. Crowley later said under oath that Wedge's reporting of the quote was not accurate. "The 'Tell her to get over it' comment is a comment that I don't know where it came from," Crowley said. "It didn't come from me."

Wedge said he stands behind what he wrote but acknowledged the quote may not have been exact. "I know he said the judge said either "She's got to get over it" or "Tell her to get over it," he said in an interview. Murphy maintains the conversation never occurred.

Two defense lawyers who were present, Anton B. Cruz and Joseph Harrington Jr., said in sworn statements that they did not see a confrontation or hear Murphy say anything about a 14-year-old rape victim.

Wedge acknowledged in an affidavit that the 14-year-old girl, who he wrote had "tearfully" read her "heart-wrenching" statement in court, in fact never spoke in court nor took the stand. And although his story referred to "several" courthouse sources, he confirmed in a deposition that he had talked with only one person who had allegedly heard Murphy make the comment.

But for a public figure, simple untruths are not enough to win a libel lawsuit; there must be "reckless disregard" for the truth. That is one reason it is almost unheard of for a judge to sue over reporting on his official conduct.

But Murphy's attorneys seized on Wedge's comments on "The O'Reilly Factor" on March 7, 2002. O'Reilly asked Wedge, "Are you absolutely 100 percent sure that Judge Murphy said that the rape victim should get over it?" Wedge answered, "Yes. He made this comment to three lawyers. He knows he said it, and everybody else that knows this judge knows that he said it." Murphy's attorneys contrasted these statements to Wedge's statements under oath, when he repeatedly answered "I don't know" or "I don't recall" to questions about the reporting and writing of his story.

Wedge also "upped the ante" by suggesting that Murphy had made disparaging remarks not only about a victim but "to victims," and by telling Fox viewers that Murphy was "coddling defendants," they claim in their briefs.

Stephen Gillers, a law professor at New York University, recalls hearing about the alleged comments about the rape victim when the story first broke. "If the judge didn't say this, you can't put it all back into the bottle -- not with all the coverage on TV and radio" he said. For the victim, the judge, the prosecutors and the reporter, Gillers added, "it will be very hard for any of them to get over it."

© 2004 The Washington Post Company



To: Grainne who wrote (91304)12/14/2004 6:49:32 PM
From: epicure  Read Replies (1) | Respond to of 108807
 
interesting story for the winter season:

Christians Aiming to Boost Religion

56 minutes ago U.S. National - AP


By ALLEN G. BREED, Associated Press Writer

Emboldened by their Election Day successes, some Christian conservatives around the country are trying to put more Christ into Christmas this season.



In Terrebonne Parish, La., an organization is petitioning to add "Merry Christmas" to the red-lighted "Season's Greetings" sign on the main government building and is selling yard signs that read, "We believe in God. Merry Christmas." And a Raleigh, N.C., church recently paid $7,600 for a full-page newspaper ad urging Christians to spend their money only with merchants who include the greeting "Merry Christmas" in ads and displays.

"There is a revival taking place in our nation that is causing Christian and right-minded people to say, `Wait a minute. We've gone too far,'" says the Rev. Patrick Wooden Sr., pastor of the Raleigh church. "We're not going to allow the country to continue this downward spiral to the left."

In California, a group called the Committee to Save Merry Christmas is boycotting Macy's and its corporate parent, Federated Department Stores, accusing them of replacing "Merry Christmas" signs with ones wishing shoppers "Season's Greetings" or "Happy Holidays." The organization cites "the recent presidential election showing political correctness is offending millions of Americans."

(Federated, for its part, says that is has no ban on such greetings and that its store divisions can advertise as they see fit and store clerks are free to wish any customer "Merry Christmas." Macy's says its ads commonly use the phrase.)

The push from the religious right troubles Barry Lynn, executive director of Americans United for Separation of Church and State.

"This mixing of secular and religious symbols ought to be seen as a bad thing, not a good thing, for Christian believers," he says. "Unfortunately, some of the Christian pressure groups seem to have it backwards." He adds: "I think it's fair to say it's a mistaken notion that they have a mandate to put more nativity scenes up because George Bush (news - web sites) was elected."

The battle over the manger on the city hall lawn is nothing new. People expect the annual tussle over the separation of church and state.

But the "keep the Christ in Christmas" contingent is particularly agitated this year over what its members see as a troubling trend on Main Street: Target stores banning Salvation Army bell ringers; UPS drivers complaining to a free-speech group that they have been told not to wish people a "Merry Christmas" (an accusation UPS denies as "silly on its face and just not true"); and major corporations barring religious music from cubicles and renaming the office Christmas bash the "end of the year" party.

"I think it is part of a growing movement of people with more traditional values, which make up the majority of people in this country, saying enough is enough," says Greg Scott, a spokesman for the Arizona-based Alliance Defense Fund.

Amid stories of schools banning the singing of carols on buses, Scott's group has distributed to more than 5,000 schools a seven-point legal primer citing 40 years of case law that says it is OK to mention Christmas in public places. And the group has about 800 lawyers waiting in the wings in case that notion needs to be reinforced.

To that same end, the Virginia-based Rutherford Institute, which says it received the UPS driver complaints, has reissued its "12 Rules of Christmas" guide to celebrating the birth of Jesus.

"I think the businesses and the schools have just gone too far; this is the final straw," says Institute president John W. Whitehead. "It's supposed to be a time of, what, peace and freedom and fun. And they've kind of made it into a secular ... kind of gray day."

Conservative radio and TV talk show hosts have chortled over some recent incidents of what they consider political correctness run amok.

In Kansas, The Wichita Eagle ran a correction for a notice that mistakenly referred to the Community Tree at the Winterfest celebration as a "Christmas Tree." And the mayor of Somerville, Mass., apologized after a news release mistakenly referred to the Dec. 21 City Holiday Party as a "Christmas Party."

But to many, the threats and demands that stores put up "Merry Christmas" signs are no laughing matter.

"Why not simply require stores owned by Jews to put a gold star in their ads and on their storefronts?" the Rev. Jim Melnyk, associate rector of St. Mark's Episcopal Church in Raleigh, wrote in a letter to the editor.



___

EDITOR'S NOTE: Allen G. Breed is the AP's Southeast regional writer, based in Raleigh, N.C. AP writer Janet McConnaughey in New Orleans contributed to this report.



To: Grainne who wrote (91304)12/14/2004 11:19:57 PM
From: Grainne  Read Replies (1) | Respond to of 108807
 
Of mice, men and in-between
Scientists debate blending of human, animal formsBy Rick Weiss

Updated: 1:14 a.m. ET Nov. 20, 2004In Minnesota, pigs are being born with human blood in their veins.

In Nevada, there are sheep whose livers and hearts are largely human.

In California, mice peer from their cages with human brain cells firing inside their skulls.

These are not outcasts from "The Island of Dr. Moreau," the 1896 novel by H.G. Wells in which a rogue doctor develops creatures that are part animal and part human. They are real creations of real scientists, stretching the boundaries of stem cell research.

Biologists call these hybrid animals chimeras, after the mythical Greek creature with a lion's head, a goat's body and a serpent's tail. They are the products of experiments in which human stem cells were added to developing animal fetuses.

Living test beds
Chimeras are allowing scientists to watch, for the first time, how nascent human cells and organs mature and interact — not in the cold isolation of laboratory dishes but inside the bodies of living creatures. Some are already revealing deep secrets of human biology and pointing the way toward new medical treatments.

But with no federal guidelines in place, an awkward question hovers above the work: How human must a chimera be before more stringent research rules should kick in?

The National Academy of Sciences, which advises the federal government, has been studying the issue and hopes to make recommendations by February. Yet the range of opinions it has received so far suggests that reaching consensus may be difficult.


• Fossil may show ape-man ancestor

During one recent meeting, scientists disagreed on such basic issues as whether it would be unethical for a human embryo to begin its development in an animal's womb, and whether a mouse would be better or worse off with a brain made of human neurons.

"This is an area where we really need to come to a reasonable consensus," said James Battey, chairman of the National Institutes of Health's Stem Cell Task Force. "We need to establish some kind of guidelines as to what the scientific community ought to do and ought not to do."

Beyond twins and moms
Chimeras (ki-MER-ahs) — meaning mixtures of two or more individuals in a single body — are not inherently unnatural. Most twins carry at least a few cells from the sibling with whom they shared a womb, and most mothers carry in their blood at least a few cells from each child they have born.

Recipients of organ transplants are also chimeras, as are the many people whose defective heart valves have been replaced with those from pigs or cows. And scientists for years have added human genes to bacteria and even to farm animals — feats of genetic engineering that allow those critters to make human proteins such as insulin for use as medicines.

"Chimeras are not as strange and alien as at first blush they seem," said Henry Greely, a law professor and ethicist at Stanford University who has reviewed proposals to create human-mouse chimeras there.

But chimerism becomes a more sensitive topic when it involves growing entire human organs inside animals. And it becomes especially sensitive when it deals in brain cells, the building blocks of the organ credited with making humans human.

In experiments like those, Greely told the academy last month, "there is a nontrivial risk of conferring some significant aspects of humanity" on the animal.

Greely and his colleagues did not conclude that such experiments should never be done. Indeed, he and many other philosophers have been wrestling with the question of why so many people believe it is wrong to breach the species barrier.

Does the repugnance reflect an understanding of an important natural law? Or is it just another cultural bias, like the once widespread rejection of interracial marriage?

Many turn to the Bible's repeated invocation that animals should multiply "after their kind" as evidence that such experiments are wrong. Others, however, have concluded that the core problem is not necessarily the creation of chimeras but rather the way they are likely to be treated.

Imagine, said Robert Streiffer, a professor of philosophy and bioethics at the University of Wisconsin, a human-chimpanzee chimera endowed with speech and an enhanced potential to learn — what some have called a "humanzee."

"There's a knee-jerk reaction that enhancing the moral status of an animal is bad," Streiffer said. "But if you did it, and you gave it the protections it deserves, how could the animal complain?"

Unfortunately, said Harvard political philosopher Michael J. Sandel, speaking last fall at a meeting of the President's Council on Bioethics, such protections are unlikely.

"Chances are we would make them perform menial jobs or dangerous jobs," Sandel said. "That would be an objection."

A research breakthrough
The potential power of chimeras as research tools became clear about a decade ago in a series of dramatic experiments by Evan Balaban, now at McGill University in Montreal. Balaban took small sections of brain from developing quails and transplanted them into the developing brains of chickens.

The resulting chickens exhibited vocal trills and head bobs unique to quails, proving that the transplanted parts of the brain contained the neural circuitry for quail calls. It also offered astonishing proof that complex behaviors could be transferred across species.

No one has proposed similar experiments between, say, humans and apes. But the discovery of human embryonic stem cells in 1998 allowed researchers to envision related experiments that might reveal a lot about how embryos grow.

The cells, found in 5-day-old human embryos, multiply prolifically and — unlike adult cells — have the potential to turn into any of the body's 200 or so cell types.

Scientists hope to cultivate them in laboratory dishes and grow replacement tissues for patients. But with those applications years away, the cells are gaining in popularity for basic research.

The most radical experiment, still not conducted, would be to inject human stem cells into an animal embryo and then transfer that chimeric embryo into an animal's womb. Scientists suspect the proliferating human cells would spread throughout the animal embryo as it matured into a fetus and integrate themselves into every organ.

Such "humanized" animals could have countless uses. They would almost certainly provide better ways to test a new drug's efficacy and toxicity, for example, than the ordinary mice typically used today.

But few scientists are eager to do that experiment. The risk, they say, is that some human cells will find their way to the developing testes or ovaries, where they might grow into human sperm and eggs. If two such chimeras — say, mice — were to mate, a human embryo might form, trapped in a mouse.

Not everyone agrees that this would be a terrible result.

"What would be so dreadful?" asked Ann McLaren, a renowned developmental biologist at the University of Cambridge in England. After all, she said, no human embryo could develop successfully in a mouse womb. It would simply die, she told the academy. No harm done.

But others disagree — if for no other reason than nothing else out of fear of a public backlash.

"Certainly you'd get a negative response from people to have a human embryo trying to grow in the wrong place," said Cynthia B. Cohen, a senior research fellow at Georgetown University's Kennedy Institute of Ethics and a member of Canada's Stem Cell Oversight Committee, which supported a ban on such experiments there.

How human?
But what about experiments in which scientists add human stem cells not to an animal embryo but to an animal fetus, which has already made its eggs and sperm? Then the only question is how human a creature one dares to make.

In one ongoing set of experiments, Jeffrey L. Platt at the Mayo Clinic in Rochester, Minn., has created human-pig chimeras by adding human-blood-forming stem cells to pig fetuses. The resulting pigs have both pig and human blood in their vessels. And it's not just pig blood cells being swept along with human blood cells; some of the cells themselves have merged, creating hybrids.

It is important to have learned that human and pig cells can fuse, Platt said, because he and others have been considering transplanting modified pig organs into people and have been wondering if that might pose a risk of pig viruses getting into patient's cells. Now scientists know the risk is real, he said, because the viruses may gain access when the two cells fuse.

In other experiments led by Esmail Zanjani, chairman of animal biotechnology at the University of Nevada at Reno, scientists have been adding human stem cells to sheep fetuses. The team now has sheep whose livers are up to 80 percent human — and make all the compounds human livers make.

Zanjani's goal is to make the humanized livers available to people who need transplants. The sheep portions will be rejected by the immune system, he predicted, while the human part will take root.

"I don't see why anyone would raise objections to our work," Zanjani said in an interview.

Mice and men
Perhaps the most ambitious efforts to make use of chimeras come from Irving Weissman, director of Stanford University's Institute of Cancer/Stem Cell Biology and Medicine. Weissman helped make the first mouse with a nearly complete human immune system — an animal that has proved invaluable for tests of new drugs against the AIDS virus, which does not infect conventional mice.

More recently his team injected human neural stem cells into mouse fetuses, creating mice whose brains are about 1 percent human. By dissecting the mice at various stages, the researchers were able to see how the added brain cells moved about as they multiplied and made connections with mouse cells.

Already, he said, they have learned things they "never would have learned had there been a bioethical ban."

Now he wants to add human brain stem cells that have the defects that cause Parkinson's disease, Lou Gehrig's disease and other brain ailments — and study how those cells make connections.

Scientists suspect that these diseases, though they manifest themselves in adulthood, begin when something goes wrong early in development. If those errors can be found, researchers would have a much better chance of designing useful drugs, Weissman said. And those drugs could be tested in the chimeras in ways not possible in patients.

Now Weissman says he is thinking about making chimeric mice whose brains are 100 percent human. He proposes keeping tabs on the mice as they develop. If the brains look as if they are taking on a distinctly human architecture — a development that could hint at a glimmer of humanness — they could be killed, he said. If they look as if they are organizing themselves in a mouse brain architecture, they could be used for research.

So far this is just a "thought experiment," Weissman said, but he asked the university's ethics group for an opinion anyway.

"Everyone said the mice would be useful," he said. "But no one was sure if it should be done."

© 2004 The Washington Post Company

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