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To: Patricia Trinchero who wrote (199777)	5/3/2009 1:42:58 AM
From: John Chen	Respond to of 306849

"The child that died in Texas " The child came from Mexico for treatment, if I get it correctly.

To: Patricia Trinchero who wrote (199777)	5/3/2009 8:18:08 AM
From: Elroy Jetson	Read Replies (2) \| Respond to of 306849

You make a really good observation. the pandemic virus of 1918 was initially not so fatal when it came onto the scene in the spring It's chance mutation which determines what happens. In general, natural selection tends to work against pathogens which kill their hosts extremely fast. The 1918 flu pandemic periodically expressed a gene which protected infected cells from programmed cell death when signaled by interferon and TNF. This made useless one of the main defenses of the human immune system. The samples of that virus which have been sequenced are from the people who died. No viral samples exist of people who were infected by the 1918 flu, but did not die. Certainly genetic variation among the human population also plays a role, but there were definitely changes in the 1918 flu over time. .