To: i-node who wrote (63518 ) 3/30/2018 3:17:05 PM From: epicure Read Replies (1) | Respond to of 354538 nature.com Was what I posted to Bentway. Read the actual science. It's pretty intriguing. Well, if you can understand it it is. "We detected several promising regions of multiple SNPs in the 10-5–10-7p -value range, as seen in the Manhattan plot (Fig. 1 ), though no SNP reached genome-wide significance (5?×?10-8). The most prominent of these regions were on chromosomes 13 (minimum p ?=?7.5?×?10-7, rs9547443) and 14 (p ?=?4.7?×?10-7, rs1035144), where some SNPs had 10-7?<?p ?<?10-6 (each region with 9 to 10 SNPs with p ?<?10-5, Table S1 ). There are a number of genes of relevance to the trait in and around these regions, which we describe below. We further note that the most significant SNP (rs77013977, p ?=?7.1?×?10-8) in the 23andMe male GWAS 29 was nominally associated (p ?=?4.1?×?10-3) in our own GWAS. We used a meta-analytic statistic that did not need direction of effect, Fisher’s combined probability test 30 , which yielded p ?=?6.7?×?10-9 for this SNP, which is the first reported genome-wide significant association for the trait. As previously noted 29 , rs77013977 is an intronic SNP in NKAIN3 , which is one of a family of four proteins (NKAIN1–4) suggested to be critical for neuronal function 31 ." With this being key "We used a meta-analytic statistic that did not need direction of effect, Fisher’s combined probability test 30 , which yielded p ?=?6.7?×?10-9 for this SNP, which is the first reported genome-wide significant association for the trait. As previously noted 29 , rs77013977 is an intronic SNP in NKAIN3 , which is one of a family of four proteins (NKAIN1–4) suggested to be critical for neuronal function 31 ." There was also the fascinating bit about the Danish study, which you probably missed- and Graves' disease and lower body weight- suggesting a linkage there too. It's a fascinating study. It's too bad you didn't read it. Or understand it. Or care. But hey, you're playing your little game- which has zero to do with science. I understand.