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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: khrnyc who wrote (1986)	1/23/1998 2:05:00 AM
From: khrnyc	Read Replies (7) \| Respond to of 7041

Continued... Yesterday I received a copy of the International Patent Application which was filed April 26, 1996 (PCT/US96/05816) It seeks both "methods and formulations for modulating the human sexual response." Some findings: Contrary to my posting #1928, vasomax is in fact a pill which is swallowed. It is "an oral formulation which comprises in combination, a vasodilator agent in a rapidly dissolving tablet." I apologize to those of you who I unintentionally led to believe otherwise. As for the method, the "invention is specifically directed" to treat "male impotence by administering a vasodilating agent in an amount effective to increase blood flow to the penis wherein erectile ablility on demand is permitted by oral administration of the vasodilator." One of the most interesting pieces of information in this patent were two tables. These tables compared the plasma concentrations (ng/ml) of drug over time after administration of a standard release phentolamine tablet and Vasomax, 40 mg each: Drug (40mg) -------- 0.25 hr 0.05 hr 0.75 hr 1.00 hr 1.50 hr 2.0 hr standard -------- --- ---- 0 ---- -- 0 ---- -- 0 ----- 0 -------- 0 --- 2.8 release (mean) Vasomax ------------- 13 ------ 17 ------ 14 ------ 12 ------ 7 ------ 0 (mean) Does anybody have the Imhof study referred to by Asencio (Jan 15, 1998)? It would be good to know what the starting dosages were of the phentolamine he refers to and whether or not the drug was administered orally, intravenously, or intramuscularly.