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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: David Bogdanoff who wrote (13827)1/28/1998 12:15:00 AM
From: Henry Niman  Respond to of 32384
 
Today's (Jan 28) issue of the FT seems to leans toward completion of the AHP/SBE merger:

Roundup
By Peter John, Martin Brice, Joel Kibazo and Melanie Senior

SmithKline Beecham led the Footsie towards a new peak as analysts
highlighted the potential benefits of a merger with American Home Products.

JP Morgan said the match was "made in heaven", with SmithKline's marketing
skills and AHP's financial discipline creating "a company whose total value is
greater than the sum of its parts".

The broker argued that a merger would lead to cost savings of between
œ1.7bn and œ2.7bn which, on revised valuations, would imply a share price of
at least 920p and at most œ11.50.

Merrill Lynch believes that top end forecast on cost savings is ambitious and
has a far more cautious view on the share price. Nevertheless, it still sees
800p as a reasonable target.

The market was also reassured by fourth-quarter figures from AHP, which
produced earnings per share in line with consensus forecasts. The absence of
anything untoward in AHP saw SmithKline Beecham jump 44 to 768p, a new
high and a 25 per cent gain over the past six weeks.

The enthusiasm for the sector and possible consolidation moved over to Glaxo
Wellcome, which jumped 64 to œ16.04. However, Zeneca fell 62 to œ23.50
despite an upbeat trading statement and several broker buy recommendations.
The stock was unsettled by a change of heart from Morgan Stanley, which cut
its recommendation from "outperform" to "neutral".



To: David Bogdanoff who wrote (13827)1/28/1998 12:26:00 AM
From: Henry Niman  Respond to of 32384
 
David, I think that the negative for a Biotech would be involvement with one of the overlapping programs. For a SBH/AHP combo, LGND could be hurt if the merged company goes with SBH SERMs instead of AHP's, but LGND has already done quite a bit of screening and I suspect that the compounds that they picked (TSE424 is first) would prevail over other compounds. I don't thing that AHP has a hematopoetic growth factor program and SBH isn't that focused on women's health, so the other programs could move foreward faster.

For a LLY/WLA combo, WLA doesn't have anything in the rexinoid area, and I suspect that LGND's TZD program is more advanced than WLA's (who just licenses Rezulin from Sankyo), so again I expect LGND's programs to benefit. LGND has a major lead in the IR screening area, so I would expect their programs to prevail over older, less specific drug discovery programs employed by big pharmas in general. Even though LGND is small, it is well focused in its two underlying core technologies.



To: David Bogdanoff who wrote (13827)1/28/1998 12:57:00 AM
From: Henry Niman  Respond to of 32384
 
Here's a Reuter's update on the big boys:

Four big U.S. drugmakers show solid profit growth (1)

Tuesday, January 27, 1998 04:20 PM

> By Ransdell Pierson

NEW YORK, Jan 27 (Reuters) - Four of the biggest U.S. drug companies on Tuesday released
strong fourth-quarter results -- two of them beating Wall Street expectations -- extending a yearlong
trend of powerful sales and earnings growth.

"We're four for four today, with solid reports by everyone. The results clearly show underlying
strong fundamental growth in the drug sector, drawn principally by volume gains," Aros Securities
analyst David Maris said.

Merck & Co. (NYSE:MRK) reported fourth-quarter net income of $1.2 billion, 19 percent higher
than the 1996 quarter, fueled by volume sales gains of established and newer prescription drugs and
further growth of its Merck-Medco Managed Care business.

Merck, whose stock is one of 30 components of the Dow Jones Industrial Average, said its basic
per-share earnings vaulted 20 percent above the 1996 quarter to $1.04 -- beating the $1.02
consensus estimate of analysts polled by First Call.

The other upside surprise came from Schering-Plough Corp. (NYSE:SGP) . It said sizzling sales
growth for its flagship antihistamine Claritin helped lift basic per-share earnings 24 percent to $0.47,
two cents above the First Call consensus.

Schering-Plough said net income rose to $343 million from $278 million in the 1996 quarter, fueled
by a 27 percent surge in worldwide pharmaceuticals growth.

It said sales growth would have been 4 percent higher if not for currency exchange factors caused
by a strong dollar in overseas markets.

American Home Products Corp. (NYSE:AHP) matched expectations with basic per-share earnings
of $0.88, 11 percent higher than the 1996 quarter. It said net income rose 14 percent to $572
million, although drug and agricultural product sales were hurt by foreign exchange fluctuations.

Warner-Lambert Co. (NYSE:WLA) also met expectations with basic per-share earnings of $0.87,
a 38 percent leap from the 1996 quarter, thanks to spirited sales of cholesterol drug Lipitor and
Type 2 diabetes drug Rezulin launched in early 1997.

"Overall, the results today show extremely high-quality growth, almost all of it driven by volume --
unlike the early 1990s when earnings were driven by price increases that weren't sustainable,"
Hambrecht & Quist analyst Alex Zisson said.

"In fact, price increases now are at or below inflation, versus two or three times the inflation rate in
1990 and 1991," Zisson said, making current earnings and sales gains that much more impressive.

Merck said company sales were $6.2 billion, up 20 percent from the 1996 quarter, adjusting for
divestiture of its crop-protection business and formation of the Merial animal-health joint venture
with Rhone Poulenc (Paris:RHON) in the third quarter. Sales growth was curbed two percent by
currency factors.

Sales of Merck blockbuster Zocor, a member of the "statin" class of cholesterol drugs, jumped 20
percent to more than $1 billion for the quarter, while sales of osteoporosis drug Fosamax rose 75
percent to $163 million. Sales of Mevacor, a less-potent, older Merck statin, fell 24 percent to
$275 million.

Rodman & Renshaw analyst Mario Corso said Merck's results were exaggerated by an unexpected
decline in its federal tax rate.

"Without that unexpected benefit, Merck's earnings would actually have fallen two cents short (of
the First Call projection)," Corso said, who added that the company's 1998 earnings should benefit
from the recent launch of its Propecia baldness drug and expected launches of asthma and migraine
drugs.

Schering-Plough said fourth-quarter worldwide sales of Claritin totaled $389 million, up 60 percent,
while sales of cancer drug Intron A rose 13 percent to $159 million.

Warner-Lambert Chief Executive Melvin Goodes said 1997 "marked the beginning of a new era"
for the company, predicting Lipitor and Rezulin would deliver "a period of sustainable double-digit
sales and earnings growth, which we believe will continue into the next millennium."

Last week, Bristol-Myers Squibb Co. (NYSE:BMY) slightly beat Wall Street expectations with
fourth-quarter basic per-share earnings of $0.81, 14 percent higher than in the 1996 period.

And Johnson & Johnson (NYSE:JNJ) said profits rose 13 percent to $630 million, matching
expectations of $0.47 a share.

Shares of Merck were up $1.50 to $115.44 late Tuesday afternoon, while Schering-Plough gained
$2.19 to $73.69. Warner-Lambert rose $5.75 to $144.69. And American Home Products moved
$2.94 higher to $93.625.

((New York Newsdesk, 212 859-1736)) REUTERS

Quote for referenced ticker symbols: AHP, BMY, JNJ, MRK, Paris:RHON, SGP, WLA



To: David Bogdanoff who wrote (13827)1/28/1998 1:02:00 AM
From: Henry Niman  Respond to of 32384
 
Reuter's also took note of the proposed merger's effect on London drug companies:

UK's FTSE 100 soars 1.7 pct to near record (1-7)

Tuesday, January 27, 1998 07:52 PM

> LONDON, Jan 27 (Reuters) - The UK's FTSE 100 index soared to a near-record closing high
on Tuesday, amid a bullish combination of bid speculation, prospects for no further rise in British
interest rates and an early advance on Wall Street.

Led by a surge in SmithKline Beecham (LSE:SB) , on hopes for its planned merger with American
Home Products (NYSE:AHP) , the FTSE 100 closed 89.1 points or 1.7 percent higher at 5,326.3
-- its highest finish since the record 5,330.8 set on October 3.


Dealers said "buy" programmes by major investment banks had helped squeeze the market higher in
the afternoon session and said record highs looked on the cards in the near term.

"It's a very illiquid market but it is up on interest rate hopes, a rising Wall Street and further hopes of
corporate activity," said a senior equity trader at one major investment bank.

Hopes for further bid activity could be encouraging investment funds to inject some of their heavy
cash holdings into the market, dealers said.

"It just feels there is an expectation of big corporate activity which is providing underpinning to the
market," said the head of equity trading at another leading investment bank, "and there is a lot of
money around."

Yet the market's strength also took many traders by surprise. "Don't ask me why it's gone up so
much because I just don't know," said one. "There is some keen buying but there is no stock
around... it is all very squeezy."

Trading volume reached a moderate 798 million shares by 1645 GMT. The Dow was up some 76
points as London closed.

A rise in Hong Kong's Hang Seng index also helped spur the UK market higher, amid hopes for a
solution to the Asian financial crisis. Heavyweight banking group HSBC (LSE:HSBA) , heavily
exposed to Asian economies, was another of the day's big gainers, recovering from recent losses to
be up 4.4 percent.

However, smaller stocks remained subdued, with the the FTSE 250 index dropping 5.5 points to
4,789.2. The All-Share index, the broadest UK market measure, gained 1.3 percent.

Some said there were signs of switching back into equities from recently outperforming bonds, after
stronger than expected U.S. fourth quarter employment cost data, an economic indicator said to be
favoured by Federal Reserve chairman Alan Greenspan. The benchmark U.S. long bond was down
9/16.

Meanwhile, hopes for no further rise in UK rates received a boost from a Confederation of British
Industry survey showing manufacturing confidence at its lowest level in over two years.

"We have a weakening economy," said Bob Semple, strategist at NatWest Securities. "Pricing
pressures are easing and it is very unlikely that the Bank (of England) will be raising interest rates.
They may have already tightened too far."

The long gilt future was down just 1/32, dragged lower by T-bonds.

Among individual stocks, financial, pharmaceutical and oil stocks led the gainers -- though Zeneca
(LSE:ZEN) was an exception among drug stocks, down 2.6 percent after Morgan Stanley cut the
stock to "neutral" from "outperform." Zeneca had earlier reassured the market that new drug
launches were going well.

Other drug stocks remained in favour, with Glaxo (LSE:GLXO) up 4.2 percent and SmithKline
(LSE:SB) up six percent -- boosted by positive analyst comment on its planned merger with
American Home Products (NYSE:AHP)
.

BP (LSE:BP) and Shell (LSE:SHEL) rallied with the oil price, after comments from the U.S. State
Department that time was running out for a diplomatic solution to the weapons stand-off between
the UN and Iraq.

NatWest repeated an "overweight" stance on the oil sector, helping lift BP, Shell and Enterprise
(LSE:ETP) by four percent or more. Lasmo (LSE:LSMR) gained two percent. Bid hopes continued
to boost selected financial stocks, with General Accident (LSE:GACC) , Lloyds TSB (LSE:LLOY)
, Norwich Union (LSE:NU) , Prudential (LSE:PRU) , Royal Sun (LSE:RSA) and Sun Life
(LSE:SLP) all up three percent or more.

PowerGen (LSE:PWG) and National Power (LSE:NPR) , however, fell for a second day as
analysts at SBC Warburg Dillon Read lowered the stocks to "hold" from "buy."

In mining stocks, Rio Tinto (LSE:RIO) lost 2.6 percent after analysts at Credit Suisse First Boston
reduced profit estimates for the 1998 fiscal year on expectations of lower copper prices.

Premier Farnell (LSE:PFL) dropped 44p or 13 percent after the deparure of its chief executive and
a profit warning.

Yet, engineering group Powerscreen International (LSE:PSI) was the day's biggest casualty, after
warning over profits and irregularities at its Matbro division. The stock plummeted 290p or 52.5
percent.

((David Holmes, London Newsroom +44 171 542-4027 fax +44 171 542-2120,
uk.equities.news@reuters.com)) REUTERS

Quote for referenced ticker symbols: AHP, LSE:BP, LSE:ETP, LSE:GACC, LSE:GLXO,
LSE:HSBA, LSE:LLOY, LSE:LSMR, LSE:NPR, LSE:NU, LSE:PFL, LSE:PRU, LSE:PSI,
LSE:PWG, LSE:RIO, LSE:RSA, LSE:SB, LSE:SHEL, LSE:SLP, LSE:ZEN



To: David Bogdanoff who wrote (13827)1/28/1998 1:08:00 AM
From: Henry Niman  Respond to of 32384
 
AP also took note of the moves by the big boys:

January 27, 1998

Earnings, Mergers Boost Drug Stocks

Filed at 6:26 p.m. EST

By The Associated Press

NEW YORK (AP) -- Drug stocks surged Tuesday on unexpectedly
strong earnings increases from three major drug makers and continued
speculation of a merger between American Home Products Corp. and
SmithKline Beecham.

Merck & Co., Schering-Plough Corp. and Warner-Lambert all reported
double-digit earnings increases as a buoyant economy lifted sales and fat
profit margins on new drugs boosted the bottom line. With sales in
troubled Asian economies amounting to only 5 percent, analysts say the
outlook for drug makers remains strong in early 1998.

The industry is reaping rewards from some of the most lucrative new drug
prices in the past couple of years, said Barbara Ryan, drug industry
analyst with Alex. Brown & Sons in New York.

Among the new products are Warner-Lambert's new
cholesterol-lowering drug, Lipitor, with starter doses retailing at $55 a
month, and Merck's new $50-a-month hair-restorer, Propecia, which
was approved by the Food and Drug Administration in December.

An August change in what regulators require drug makers to disclose in
television advertisements has also led to a boost in direct-to-consumer
marketing. That, in turn, has boosted sales of popular prescription drugs
such as Merck's cholesterol drug Zocor and Schering-Plough's
antihistamine Claritin.

Warner-Lambert shares bolted $6.50 to $145.43 3/4, Schering-Plough
shares rose $1.75 to $73.25 and Merck shares rose 50 cents to $114.50
on the New York Stock Exchange.

American Home stock rose 2 percent -- up $2.06 1/4 to $92.56 1/4 --
despite earnings near Wall Street expectations. Analysts said the rise was
due to continued speculation in the company's ongoing merger talks with
the rival British drug maker, increasing earnings momentum following an
11 percent decline in third-quarter profits, and an FDA advisory panel's
recommendation Tuesday that the agency approve the company's
hypertension drug, Verdia.

SmithKline's U.S.-traded shares rose $1.31 1/2 to $62.50.

American Home came out of a difficult year in which it recalled two diet
drugs and faced numerous lawsuits with a fourth-quarter rise of nearly 12
percent.

The company faces lawsuits from thousands of former diet drug users and
women who used the Norplant surgically implanted contraceptive. But
the first of a series of claims from Norplant users ended in a mistrial in
Texas last week, and the company has downgraded its worst-case
estimates of how much the diet drug suits might cost them to $2 billion or
$3 billion, according to one analyst.

''As big as it sounds, that number is half what other people have said --
$4 billion to $8 billion,'' said David Saks, a health care industry analyst
with Gruntal & Co. in New York.

Deutsche Morgen Grenfell analyst Mariola Haggar puts the company's
maximum liability at $2.8 billion.

The Madison, N.J.-based maker of Advil pain relievers, Centrum
vitamins and Premarin estrogen earned $571.8 million, or 87 cents a
share on a diluted basis, compared with $511.6 million, or 79 cents per
share, a year earlier. Fourth quarter sales rose 4 percent to $3.61 billion.

Warner-Lambert showed the biggest jump in fourth-quarter profit. The
38 percent earnings rise came largely on the strength of the Morris Plains,
N.J.-based company's cholesterol and diabetes drugs.

The maker of Zantac heartburn medication, Benadryl antihistamine and
Listerine mouthwash earned $235.7 million, or 84 cents a share on a
diluted bases, compared with $171 million, or 62 cents a share, in the
comparable 1996 quarter.

Sales were $2.33 billion in the fourth quarter, up 26 percent from $1.84
billion for the same period last year.

The company's drug sales rose 45 percent to $3.6 billion in 1997, led by
$865 million in annual sales of Lipitor and $420 million in annual Rezulin
sales.

Close behind Warner-Lambert in profit increases was Schering-Plough,
which reported a fourth-quarter earnings increase of 23 percent.

The Madison, N.J.-based company earned $343 million, or 46 cents per
share on a diluted basis, in the fourth quarter. That compares with
earnings of $278 million, or 37 cents per share, in the fourth quarter of
1996.

Sales rose 26 percent, to $1.78 billion from $1.41 billion, led by
revenues from the Claritin line and Intron A, an antiviral-anticancer agent.

Earnings for Merck rose 19 percent in the fourth quarter.

The Whitehouse Station, N.J.-based drug maker earned $1.24 billion, or
$1.01 per share on a diluted basis, in the fourth quarter, compared with
$1.04 billion, or 84 cents per diluted share, in the comparable 1996
period.

Sales rose 15 percent to $6.23 billion, driven by sales of Zocor, the line
of gastric acid medications, the Crixivan protease inhibitor for HIV
infection and Fosamax for treatment of postmenopausal osteoporosis.

Related Information From Hoover's Inc.
Schering Plough
Merck & Co
Smithkline Beecham PLC
American Home Products
Warner Lambert



To: David Bogdanoff who wrote (13827)1/28/1998 7:00:00 AM
From: Henry Niman  Respond to of 32384
 
This morning, the WSJ also commented on the performance of drug stocks and income:

The Wall Street Journal -- January 28, 1998
Corporate Earnings:
Prescriptions and Hot Products
Aid Drug Firms

---
Net at Warner-Lambert, Merck, Schering-Plough, American
Home
Rises
----

By Robert Langreth
Staff Reporter of The Wall Street Journal

Several blockbuster drugs, and the inability of managed-care companies to
restrain doctors' prescribing habits, helped four major drug companies post
sharply higher fourth-quarter earnings.

Each company -- Merck & Co., American Home Products Corp.,
Schering-Plough Corp. and Warner-Lambert Co. -- reported double-digit
income gains on strong sales of drugs for lowering cholesterol levels,
controlling diabetes, and reducing the symptoms of allergy. Driving the healthy
sales were aggressive and increasing marketing campaigns aimed at doctors
and consumers.

Just a few years ago, industry executives and analysts were predicting that
health-maintenance organizations would reign in doctors' prescribing practices,
and render drug companies' sales forces ineffective. But the managed-care
industry's efforts to contain such costs have largely failed, leaving little to
prevent drug companies' aggressive marketing efforts from succeeding.

As a result, the number of drug sales representatives has grown by 40% during
the past three years, analysts say. Meanwhile, TV advertising of drugs is
exploding because of loosened regulations, prompting new patients to visit
their doctors and demand prescription drugs by name.

"It's a party in the pharmaceutical industry these days," said industry analyst
Carl Seiden of J.P. Morgan. "Managed care can't control anything, and there
is no evidence of its getting its act together [in the short-term]. Drug companies
are finding totally new ways of marketing."

Merck said net income rose 19%, driven by higher sales of its cholesterol
medication Zocor and improved sales of a line of high-blood pressure drugs.
American Home Products' net rose 12% on a 3.8% rise in sales; excluding
special items resulting from the sales of its foods unit and the acquisition of a
biotechnology unit, the net would have risen 14%.

Schering-Plough net climbed 24% on a 60% rise in sales for its allergy drug
Claritin, while Warner-Lambert's net jumped 38% amid strong sales gains for
its Lipitor cholesterol drug and a new diabetes drug. Nevertheless, sales at all
four companies were held down by the impact of unfavorable foreign-currency
exchange.

The companies' results were either in line with or slightly higher than analysts'
expectations, and all of their stocks closed higher. In New York Stock
Exchange composite trading, Merck shares rose 50 cents to $114.50, while
shares of American Home climbed $2.0625 to $92.5625. Shares of
Schering-Plough gained $1.75 to $73.25, and Warner-Lambert shares rose
$6.8125 to $145.75.

Merck's net rose to $1.24 billion from $1.04 billion. Under new accounting
standards that went into effect late last year, companies must report per-share
earnings in two redefined ways, diluted and basic. Diluted earnings per share,
or net divided by common shares outstanding plus potential common shares
from options or convertible securities, rose 20% to $1.01 a share from 84
cents, while basic earnings per share, or net divided by common shares
outstanding, also rose 20%, to $1.04 from 87 cents.

Sales for the Whitehouse Station, N.J., company grew 15% to $6.23 billion.
Sales would have increased 20% if figures are adjusted to account for the
effects of the sale of the company's crop-protection business and the formation
of a joint venture to sell animal-health products.

In particular, sales of the cholesterol drug Zocor increased 20% to $1 billion in
the quarter. But much of that increase came at the expense of its companion
drug Mevacor, sales of which fell 24% as Merck shifted its marketing
emphasis toward Zocor. Overall, U.S. drug sales rose 17%.

American Home, Madison, N.J., said net income rose to $571.8 million from
$511.6 million, while diluted earnings per share rose 10% to 87 cents from 79
cents. Basic earnings per share rose 10% to 88 cents from 80 cents.

Sales rose to $3.61 billion in the quarter. Strong initial sales of a new
prescription pain killer, Duract, partially compensated for lost revenues
because of the September recall of the company's diet drugs Redux and
Pondimin. The company, which acknowledged last week it has been in merger
negotiations with British drug giant SmithKline Beecham PLC, managed to
post a double-digit increase in net income in part because of significantly lower
income taxes in the quarter compared with last year.

Separately, a Food and Drug Administration advisory panel yesterday
recommended the agency approve one potential new American Home drug,
Verdia for high-blood pressure.

Two smaller companies posted the largest sales gains of the four companies.
Merck's major new competitor in the cholesterol-drug market,
Warner-Lambert's net rose to $235.7 million from $171 million. Diluted
per-share earnings rose 35% to 84 cents from 62 cents, while basic earnings
per share increased 38% to 87 cents from 63 cents. Sales jumped 26% to
$2.33 billion.

The Morris Plains, N.J. company, once known for a lackluster new-drug
pipeline, has become a rising star in the industry following the introduction last
year of Lipitor for lowering cholesterol and Rezulin for diabetes. Lipitor, which
lowers cholesterol significantly more than competing drugs, has garnered a
greater share of new prescriptions than Merck's Zocor, the current top-selling
cholesterol drug. The drug, which is co-marketed by Pfizer Inc., had sales of
$408 million in the quarter and $865 million for 1997, and is on its way to
becoming one of the best-selling prescription drugs ever.

Rezulin seems to be weathering a scare last fall over possible liver side-effects,
analysts said. Its sales rose to $177 million in the quarter from $137 million in
the third quarter. More importantly, the number of new prescriptions written
each week for Rezulin has started to rise again, analysts said.

Schering-Plough, Madison, N.J., said net rose to $343.3 million from $277.8
million, while diluted earnings per share rose 24% to 46 cents from 37 cents.
Basic earnings per share climbed 24% as well to 47 cents from 38 cents.

Revenue increased 26% to $1.78 billion, largely because of the company's
phenomenally successful Claritin line of prescription allergy drugs. Claritin sales
rose 60% to $389 million for the quarter, in part due to a successful
television-advertising campaign. Some analysts predict the drug will top $3
billion in sales by the year 2000. Sales of Imdur for heart disease also rose
strongly.

---

Blockbuster Results
FOURTH-QUARTER 1997
-------------------------------------------
NET INCOME % CHANGE DILUTED % CHANGE
(in millions) FROM '96 PER SHARE FROM '96
AHP $ 571.8 +11.8% 0.87 +10.1%
Merck 1242.3 +19.1 1.01 +20.2
Schering-Plough-a 343.3 +23.6 0.46 +24.3
Warner-Lambert 235.7 +37.8 0.84 +35.5
12-MONTH
-------------------------------------------
NET INCOME % CHANGE DILUTED % CHANGE
(in billions) FROM '96 PER SHARE FROM '96
AHP-b $2.04 + 8.5% 3.11 + 6.5%
Merck 4.61 +18.9 3.74 +19.9
Schering-Plough-a 1.44 +19.0 1.95 +19.6
Warner-Lambert-c 0.87 +10.6 3.11 + 9.1

a-Schering-Plough results include revenues from the acquisition of
Mallinckrodt Veterinary in June 1997.

b-full year 1997 results include a $117 million after-tax charge related to the
recall of two diet drugs.

c-Warner-Lambert 1996 full-year results include a $75.2 million, or 17 cents a
share, gain related to the sale of its generic pharmaceuticals business.



To: David Bogdanoff who wrote (13827)1/28/1998 7:54:00 AM
From: Henry Niman  Read Replies (1) | Respond to of 32384
 
NY Times commented on "Banner Profits" for big boys:

January 28, 1998

Drug Makers Post Banner Profits in
Quarter

Graphic
Pharmaceutical Profits

By DAVID J. MORROW

uoyed by a strong demand for drugs that reduce cholesterol and
treat diabetes and allergies, four major American drug companies
reported strong fourth-quarter earnings Tuesday, capping one of the
industry's most profitable years.

The reports raised the stocks of all four companies: Shares of
Warner-Lambert were up $6.8125, to $145.75. Merck & Co. gained
50 cents, to $114.50. Schering-Plough closed at $73.25, up $1.75. And
American Home Products, which confirmed last week that it was in
merger talks with SmithKline Beecham, gained $2.0625 to close at
$92.5625.

Though all four companies met or exceeded most analysts' expectations,
Warner-Lambert, based in Morris Plains, N.J., was the big winner. Its
earnings rose 37.8 percent, to $236 million, or 84 cents a diluted share,
from $171 million, or 62 cents a share, a year earlier.

For the year, Warner-Lambert earnings rose 11 percent, to $870 million.

Much of the gains came from Warner-Lambert's cholesterol-reducing
drug Lipitor, which racked up $865 million in sales in its first 11 months
-- the most ever for any first-year drug -- and from Rezulin, a diabetes
drug that appears to have survived a recent marketing scare.

Glaxo Wellcome PLC, which sells a version of Rezulin in Britain, halted
sales of the drug there in December because of health concerns. That
caused Warner-Lambert's stock to plunge 18.5 percent, to $114 a share,
because of worries that the Food and Drug Administration might limit
sales in the United States. In one day, the setback shaved $7 billion off
the company's market value.

Analysts had feared that consumers would replace Rezulin with other
drugs. But that does not appear to be the case. Rezulin had $420 million
in sales last year, enough to prod nervous investors to take their shares
back. Within the last six weeks, Warner-Lambert's stock has recovered
from its December avalanche.

"Warner-Lambert is in a strong position for great growth," said Neil
Sweig, a pharmaceuticals analyst with Southeast Research Partners. "I
expect the company to report a 30 percent earnings gain for 1998. Their
pharmaceuticals are selling so well you don't even look at the company's
other divisions."

Blockbuster drugs were the story of 1997 earnings. Nowhere was that
more apparent than at Schering-Plough, which is based in Madison, N.J.,
and is best known for its allergy treatment, the antihistamine Claritin.
Thanks in part to an aggressive television advertising campaign,
worldwide sales of Claritin increased 50 percent last year, to $1.7 billion.

The boom helped the company notch a 23.4 percent gain in
fourth-quarter earnings, to $343 million, or 46 cents a diluted share, from
$278 million, or 37 cents a share.

For the year, earnings rose 19 percent, to $1.44 billion.

Merck, based in Whitehouse Station, N.J., lifted its earnings by 19.1
percent in the fourth quarter, to $1.24 billion, or $1.01 a diluted share,
from $1.04 billion, or 84 cents a share, in the comparable 1996 period.

The gain came largely because of sales of Zocor, a cholesterol reducer,
and Fosamax, Merck's osteoporosis drug.

For the year, earnings rose 19 percent, to $4.6 billion.

Of the day's reports, the least impressive was the one by American Home
Products, which is also based in Madison, N.J. Since the company
confirmed its merger discussions with SmithKline Beecham last week, it
has been under the scrutiny of investment bankers and analysts alike.

Tuesday's earnings report did not bring any surprises. Earnings rose 11.8
percent, to $572 million, or 87 cents a share, in the fourth quarter, from
$512 million, or 79 cents a share, a year earlier.

For the full year, they rose 8.5 percent, to $2.04 billion.

"The possible merger with SmithKline Beecham has a life of its own," said
David F. Saks, senior vice president at Gruntal & Co. "Whatever
developments or earnings the company announces may not be able to
replace that in investors' minds."

One item from the earnings report may enter into the merger talks. Wall
Street analysts have pondered whether American Home Products might
sell its agricultural products business to raise money and lift its stock
price. Sales at the agricultural business were up 15 percent in the fourth
quarter and 7 percent last year, to finish at $2.1 billion.

"American Home Products merely met the market's expectations," Sweig
said. "It was neither way up or way down. But with the merger, the
company didn't have to do anything more than that."

The sales at all four companies were adversely affected by the strong
dollar. American Home Products, for example, reported that the
unfavorable currency exchange rate lowered its worldwide net sales 4
percent in the fourth quarter and 3 percent for the year.