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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: Bill Wexler who wrote (2103)	1/28/1998 5:25:00 PM
From: C. K. Humphries	Read Replies (1) \| Respond to of 7041

I'm not sure if this info below has been previously posted. It also makes me question what is so special about Zonagen's drug. There are two other ways you may be able to help your patients: URETHRAL GEL and ORAL PHENTOLAMINE. Many patients have successfully tried these alternatives to injectables. The urethral gel is inserted into the urethra via a special syringe or applied topically. Oral phentolamine can be taken in an oral dosage which can be swallowed or placed under the tongue. This oral phentolamine may be an alternative to the injection for many impotent men. "Satisfactory erection with penetration can be obtained in impotent men by the oral or buccal administration of the alpha-adrenergic antagonist, phentolamine. This agent is also used in conjunction with papavarine HCl for intracavernous injection." 1 1. "Experience with buccal phentolamine mesylate for impotence," Zorgniotti, A.W., Dept. Of Urology, New York University School of Medicine, NY 10016, Int J Impotence Res., 1994 Mar, 6:1, 37-41.Order this document Int J Impot Res 1994 Mar;6(1):37-41 Experience with buccal phentolamine mesylate for impotence. Zorgniotti AW Department of Urology, New York University School of Medicine, NY 10016. Satisfactory erection with penetration can be obtained in impotent men by the oral or buccal administration of the alpha-adrenergic antagonist, phentolamine. This agent is also used in conjunction with papaverine HCl for intracavernous injection. The previous observation by Gwinup, that 50 mg of phentolamine HCl po, 1.5 hours before coitus resulted in erection in 11/16 patients, is confirmed. This study, using phenoxybenzamine as the placebo, was repeated with success in 36/85 (42.3%) patients. Because of cost and to decrease the waiting time, a buccal form of phentolamine mesylate was administered (20 mg) with erection and penetration in 21/69 (31.8%). There was no correlation between the degree of penile vascular insufficiency or age and the effectiveness of phentolamine. Buccal phentolamine is shown to increase flow velocity in the dorsal penile artery. Phentolamine produces minimal side effects, including hypertension in the subjects. Publication Types: Clinical trial PMID: 7517275, UI: 94290566

To: Bill Wexler who wrote (2103)	1/28/1998 5:44:00 PM
From: Dr. Voodoo	Read Replies (2) \| Respond to of 7041

Yes but, nothing about the components of many of the drugs that people make are unique, have a novel manufacturing process, or a novel delivery method. My interpretation of what they are attempting to patent is the rapid delivery of phentolamine as a therapy to treat impotence, not their formulation. For instance, If I were a doctor and I decided I wanted to treat ED, I would be prohibited from violating their patent by giving someone phentolamine in any rapidly absorbable fashion. In fact it clearly states that other methods of delivery are part of their claims. For instance a shot in the arm, dissolving it in water and drinking it. I wonder if this is a patentable claim. For instance I could try to patent driving my car as a means to get to work, but the process of driving and getting to work are too obvious. Thoughts anyone?