To: Thomas M. who wrote (3104 ) 6/9/2024 12:37:28 PM From: Thomas M. 2 RecommendationsRecommended By
Respond to Paxlovid and Molnupiravir appear to be totally ineffective. Molnupiravir is so dangerously mutagenic that you need to use contraception for weeks after taking it. But they can make huge profits for drug companies, unlike Ivermectin or OTC nasal sprays.Molnupiravir or Paxlovid versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial In adults hospitalised with COVID-19, neither molnupiravir nor nirmatrelvir-ritonavir were associated with reductions in 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or deathmedrxiv.org Analysis:RECOVERY RCT showing no significant differences in mortality, ventilation, or discharge with either molnupiravir (923 patients) or paxlovid (137 patients). Viral load was improved with treatment but did not translate into clinical benefit, which may in part be due to side effects of treatment. The treatment delay was notably shorter compared to other treatments in this trial - 4 and 5 days from onset for paxlovid and molnupiravir. There was an exactly one year delay in publication after completion of recruitment. No press release or results are shown on the trial web site. In contrast, a press release was issued for the HCQ arm on the same day that recruitment ended. The one year delay may be a maximum delay due to EU Clinical Trials registration and associated regulatory requirements for the release of results within 12 months. Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer. c19early.org
