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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: Hank who wrote (3042)	3/25/1998 9:42:00 PM
From: Brander	Read Replies (2) \| Respond to of 7041

Hank, in regards to the question about the difference in Mechanisms, I would like to add my 2 cents. Viagra is not a direct vasodilator, as I understand it. It's mechanism of action results in increased blood flow to the pelvic area, and, with proper sensory input, it helps to keep the blood where it needs to be. Phentolamine is a direct, short acting, general vasodilator, working by blocking alpha adrenergic receptors. Their mechanisms of action are very different. Interestingly, Viagra was originally tested as a cardiac medication. The thought was that it would increase blood flow to cardiac tissue. During the trials, investigators were perplexed as to why some of the subjects did not want to stop the medication. Upon further investigation, it was found that some men who had been impotent for some time were now having erections. It was later found to have no effect on the blood flow to cardiac tissue, but to, instead, increase blood flow to the pelvic area. After today, it looks more like we might have two oral medications to choose from for treating impotence. I was beginning to lean toward the short side of the fence concerning Vasomax, but todays news is certainly progress towards possible FDA approval of Vasomax. It shows that it is unique enough to deserve a patent. Brad