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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: David L. Hachey who wrote (18435)4/1/1998 12:36:00 PM
From: Flagrante Delictu  Read Replies (1) | Respond to of 32384
 
David, It's a pleasant surprise to learn that practicing scientists are willing to wade through the pseudo- babble most of us stock jockeys deposit on this thread. Thanks for volunteering to inform the astute afficionados. Hopefully, they will then interpret it for the rest of us. Please keep posting.



To: David L. Hachey who wrote (18435)4/1/1998 1:53:00 PM
From: tuck  Read Replies (1) | Respond to of 32384
 
David,

Ligand may want to keep their numbers to themselves for the time being. But there may be some papers accompanying Phase I/II trials that mention the spike in numbers, and whether or not a meal was part of the protocol. These may be in the public domain, and perhaps Henry knows where to look. For a couple of weeks I'll be out of touch with my source, who may or may not a) know the numbers, or b) feel at liberty to tell.

I would guess that Ligand's scientists didn't clutter the dose with a meal that would produce the same effect. A meal shouldn't be necessary for a small molecule drug, should it?

Regards, Tuck



To: David L. Hachey who wrote (18435)4/1/1998 7:25:00 PM
From: Biotech Jim  Read Replies (2) | Respond to of 32384
 
Does either glucagon-like peptide or glucose-dependent insulinotropic peptide secretion after a meal impact upon the serum triglyceride rise? I do not know of any literature directly examining this, but I wonder whether in the trial design there was an effect on gastrointestinal hormonal secretion? What other mechanisms might be worthy of pursuit in the addressing of this potentially toxic issue?

BJ