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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?

To: Beverly-Joe who wrote (929)	4/2/1998 8:40:00 AM
From: Mr.Manners	Respond to of 9523

You might possibly get your answers by asking PFE on their site page.

To: Beverly-Joe who wrote (929)	4/2/1998 6:12:00 PM
From: Perry	Respond to of 9523

I recall reading in the FDA documents that Viagra is not teratogenic in animals (rats) and just as important does not decrease sperm count. I know this information can be obtained on line from the FDA web site. It should be stated that the number of species tested was not made clear in this report. This may be an issue, since you most likely know,thalidomide is not teratogenic in rodents but is extremely teratogenic in rabbits. I would hope that drug companies and the FDA have learned a valuable lesson from these earlier tragedies. Regardless, Viagra is taken by men and hence the drug would need to be tranferred to his partner through sexual intercourse. It is questionable if concentrations can be reached within the uterus that could be teratogenic. I have not come across any studies that demonstrate male-mediated birth defects, in this manner, although I do believe they exist. Can you relay some current studies? Thanks and I hope this helps. Perry

To: Beverly-Joe who wrote (929)	4/2/1998 6:23:00 PM
From: Barron Von Hymen	Read Replies (3) \| Respond to of 9523

Why would women want to take a drug that enhances penile erections when they don't have a penis? I ask this b/c of your question related to safety issues concerning pregnant women. If you're concerned that the male would expel some Viagra in his ejaculate, and therefore get into the women's system. Only 0.001% of administered dose appears in the semen in healthy volunteers (FDA web page). Concerning thalidomide, the industry remembers the thalidomide case and uses the thalidomide as a case and point to ensure that those tragic events don't happen again. I think they screen very carefully for teratogenic effects, very early in drug development and screening is tougher than the thalidomide's time. So I'm wondering if the rumour I heard of Viagra working in women isn't bull crap? Could they be marketing the drug for women? Maybe Viagra works by enhancing neural stimulation of blood flow to the clitoris? What is the corresponding condition for erectile dysfunction in women, is it just sexual dysfunction? Does anyone know the frequency of occurrence in women? So if Viagra alleviates sexual dysfunction in women, the estimates given by analysts are way too low since they consider the drug only being administered to men.