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To: Lady Lurksalot who wrote (10081)4/20/1998 8:04:00 PM
From: Jacques Chitte  Read Replies (1) | Respond to of 71178
 
I'll have to do a quickie search on the current state of affairs re prions. Absent a better hypothesis (and a kuru virus is, for now,in the same league as that second AIDS pathogen making the rounds a few years ago - a great way to make a virologist spray beer) there's a central nervous system protein called PrP which goes bad. Seeds its own badness, so a contaminated spot grows. Like ice crystals in supercooled water. As far as I know, that's still the leading hypothesis. I'd hazard that the entry in the Merck Manual was influenced by an editor's disdain of abiotic pathogenesis. It's not a very elegant theory - so - we just haven't found the virus yet! :-)

That saxophonist must have had marvelous collateral circulation.