To: Jeffrey L. Henken who wrote (556 ) 4/25/1998 7:14:00 PM From: Aishwarya Read Replies (1) | Respond to of 2887
Blood Test for Latex Allergy Reprinted from Medical Sciences Bulletin , published by Pharmaceutical Information Associates, Ltd. Diagnostic Products Corporation has received approval to market its latex allergy test (AlaSTAT), the first blood test to become available for identifying individuals who are hypersensitive to latex. The test should help physicians cope with the increasing problem of latex allergy. Latex, a natural rubber, is used in a wide variety of products that come into contact with human skin and other body surfaces. In the health care field, latex products include gloves, catheters, baby- bottle nipples, condoms, and diaphragms. About 1% of the general population is believed to be allergic to latex. Persons with latex allergy can suffer cutaneous, respiratory, and systemic responses. The most common manifestation of latex allergy is nonimmunologic irritant dermatitis of the hand. Contact dermatitis (type IV delayed hypersensitivity reactions to additives in the rubber) is the most frequent form of immunologic reaction. Less common are type I allergic responses such as contact urticaria, rhinoconjunctivitis, asthma, and anaphylaxis. An estimated 7% to 10% of health-care workers regularly exposed to latex and 28% to 67% of children with spina bifida have positive skin test results for latex proteins, indicating increased blood titers of immunoglobulin E (IgE). The AlaSTAT test measures specific IgE antibodies against latex. The in vitro test is performed on a blood sample and takes about 3.5 hours. In the four-step procedure, specific IgE binds to B-allergen. The antibody-allergen complex is then bound to a biotin-coated tube. Enzyme-labeled anti-IgE antibody is added, and the resulting complex is reacted with an enzyme substrate. If the specific anti-latex IgE is present in the blood sample, the substrate reaction causes the sample to become colored. AlaSTAT is intended for diagnosis of patients with suspected latex allergy. It is not intended as a screening tool. If a patient tests positive, measures can then be taken to avoid exposure to latex products. According to the American Academy of Allergy and Immunology (AAAI), four groups of people are at risk for latex allergy: health-care workers, latex industry workers, children with spina bifida, and persons with positive risk factors (e.g., multiple surgeries; reactions to products containing latex; hand eczema; unexplained anaphylaxis; oral sensitivity to avocados, bananas, kiwi fruit, or chestnuts). AAAI recommends testing of individuals in these groups before they are exposed to latex during health care. The manufacturer claims that the test has a clinical sensitivity of 91% to 100%, and that the predictive value of a negative result is 99% for a population with a 10% prevalence of latex allergy. BTW: Just FYI on latex allergy. ABMI will have its day. A lot of people on yahoo were concerned that the stock is not doing wondrs. It takes time but miracles are for real and situations change overnight. The patient will make their money and impatint will loose money to day traders who operate faster than them. ABMI is just fine as it was a couple of weeks back. The newly designed web site should be up soon. Can you find a tentative date on when the site will be up Jeff ? Regards, Sri.