To: ChinuSFO who wrote (116 ) 5/29/1998 11:48:00 PM From: Anthony Wong Respond to of 1722
(AP)- Drug Cos. Work on Impotence Drug MAY 29, 21:37 EDT By EILEEN GLANTON AP Business Writer NEW YORK (AP) - While the frenzy for Viagra continues, drug companies are developing competitors that could work faster or eliminate some of the side effects of the impotence treatment. The market is vast and its growth has been phenomenal. More than 1 million men have filled prescriptions for Viagra, made by Pfizer Inc., since it was approved by federal regulators March 27. Analysts say Viagra could reach $1 billion in sales this year. The next impotence drug isn't likely to emerge until next year, and by then, drug makers looking to cut into Viagra's market share may fare better if their treatments work faster or last longer. ''The second or third drug on the market, as long as it's safe and effective, should also do well,'' said Hemant K. Shah, an independent industry analyst in Warren, N.J. ''But Viagra will be quite entrenched.'' Zonagen Inc., of The Woodlands, Texas, may be next in line. It recently completed clinical tests on Vasomax, which dissolves more rapidly in the stomach than Viagra. Jean Anne Mire, the company's vice president of investor relations, said a sexually stimulated patient can develop an erection within 15 to 30 minutes of taking Vasomax. Doctors recommend taking Viagra about an hour before sex. Zonagen expects to formally ask the U.S. Food and Drug Administration to approve the drug by the end of June, Mire said. Tap Pharmaceuticals' apomorphine is in the final stages of clinical trials, and could be used alone or in combination with Viagra, said Dr. Harin Padma-Nathan, director of the Male Clinic in Santa Monica, Calif. Apomorphine affects the brain chemicals responsible for sexual response, whereas Viagra works directly on the penis. Pfizer itself is working on a Viagra wafer that could dissolve in the mouth in seconds, which would let patients take the drug only minutes before sex. Future impotence drugs may also be designed to eliminate some of the side effects experienced by Viagra users. Little-known Icos Corp., of Bothell, Wash., saw its stock rise 30 percent Friday after Business Week magazine reported its impotence drug causes fewer side effects than Viagra. Lacy Fitzpatrick, associate director of investor relations for Icos, said its drug, which doesn't yet have a brand name, could come to market in 2000. Like Viagra, it blocks enzymes that inhibit erections, but it targets the enzymes more selectively. Most Viagra users have experienced mild side effects, including a stuffy nose, headaches, and a blue tinge to the vision. Six Viagra users have died, three due to a combination of Viagra with nitroglycerin or related heart drugs. The other deaths have been attributed to heart attacks or strokes following sex. Pfizer warns patients not to combine Viagra with nitrates. Padma-Nathan said that given the large number of Viagra users, and the fact that most have existing health problems, the side effects have been minimal. ''This drug really is the gold standard,'' he said. ''It is exceedingly safe.'' Meanwhile, the market for Viagra appears poised to expand. A scientific advisory panel Friday gave Viagra a positive review in the European Union, improving its chances for being sold in its 15 member nations.