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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?

To: Henry Niman who wrote (21895)	6/5/1998 12:33:00 PM
From: Hippieslayer	Read Replies (1) \| Respond to of 32384

As long as lgnd shows that it cures rats, maybe we will see a 2-3 point gain!

To: Henry Niman who wrote (21895)	6/5/1998 12:35:00 PM
From: Mudcat	Read Replies (5) \| Respond to of 32384

<The implications of the upcoming Science article are huge> So Henry, who owns this fascinating science and the patents,Lgnd or SBH? Or will they be shared where Lgnd gets single digit % royalty and SBH the remainder.

To: Henry Niman who wrote (21895)	6/5/1998 1:20:00 PM
From: dwc	Respond to of 32384

>This initiates a signal transduction pathway that involves various intermediates,culminating with transcription factors that alter gene expression. < Henry: Do they have a course in Layman 101 at your school.

To: Henry Niman who wrote (21895)	6/5/1998 1:42:00 PM
From: Machaon	Read Replies (2) \| Respond to of 32384

<< The approach allows for screening of anatgonists as well as agonists and the compounds can be made and modified very cheaply. Thus, the various established Biotech products are fair targets, as are many of the current products under development. >> That was quite an interesting and complex note to Andrew. I pulled out one, of several paragraphs, for which I would appreciate it, if you could explain a little more. Why are established Biotech products "fair targets"? Thanks, Bob

To: Henry Niman who wrote (21895)	6/6/1998 1:26:00 AM
From: WTDEC	Read Replies (2) \| Respond to of 32384

Henry, I don't think most people appreciate how far advanced LGND is with finding small molecules that interact with the transcription factors (or associated proteins) to mimic the effect of polypeptide hormones. At its recent meeting with analysts, LGND indicated it was close to finding a small molecule mimic for interferon. It was emphasized there were still a few problems to solve, but they felt a compound is likely by sometime in 2000 which will, in turn, be in humans in 2001. Have you heard anything about this? Regards, Walter