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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?

To: Henry Niman who wrote (23448)	7/22/1998 10:19:00 PM
From: Machaon	Respond to of 32384

<< Today the Keystone State Stealers won 16-2 >> Fortunately, I skipped over all of the unimportant news, about LGND, to get to the important sports results! <g> Fast-pitch world series??? I thought that you managed a soccer team? << Under the new rules, a company can promote off label uses. I believe that the requirement for promotion is publication in one or two peer reviewed articles. >> I can see why you are so "into" Ligand. It takes something like 10 years to get a new drug thru the FDA, more or less. If Targretin or Panretin turn into successful drugs, they can get the new indications into the market extremely fast! Ligand's business plan is very impressive. Target small, under-served populations, to get fast track approval. One biggy could be Targretin for breast cancer. If Ligand gets Targretin capsules approved next year for CTCL, and the clinical trials show efficacy against breast cancer, the move to market could be done very quickly, right? Do you know how long it takes to get "peer reviewed" articles? Just because this sounds very hypish, I want to say that most biotech investments are considered fairly high risk, so people should do their own research and make their own decisions. Regards, Bob

To: Henry Niman who wrote (23448)	7/22/1998 10:36:00 PM
From: RXGOLF	Read Replies (1) \| Respond to of 32384

Off Topic <<P.S. Today the Keystone State Stealers won 16-2, so I'm still in Columbus at the fast pitch World Series>> Hello Henry. What age group are the girls competing in, how many feet away is the pitchers rubber, and how fast are they throwing? Seems as if 16 runs is a bunch for the caliber of pitchers at the world series. Do you think Ligand will be able to knock out a few hits anytime soon, or are we destined to languish until profitability is reached in a year or so? When you left the company, did you ever dream they would have 5 drugs in front of the FDA this soon? Even counting the balk on Ontak, looks like we have ducks on the pond. If we can just avoid any wild pitches, and bring 2 or 3 of the 5 home, profitability should be a reality before the year 2000, and some here at the ball park can quit crying in their beer. I for one am still root, root, rooting for the home team, and we all know if they don't win it's a shame<g>. Have fun Henry, and good luck to the girls. RXGOLF

To: Henry Niman who wrote (23448)	7/23/1998 11:54:00 PM
From: Machaon	Respond to of 32384

<< Bob, A physician can legally prescribe an FDA approved drug for any condition that the physician deems beneficial >> I was looking thru the 1997 annual report again. There is a lot there, relating to possible off-label use. One particularly caught my attention. "Targretin Gel is also in Phase II trials for the treatment of actinic keratoses, a condition which may become cancerous. ... Actinic keratosis, a skin condition affecting approximately 2.8 million people in the U.S. ..." Besides all the other diseases, once, and if, Targretin gets approved for CTCL next year, it could possibly be prescribed for this huge (2.8 million) off-label application. I looked thru your web site for more info on the Phase IIa trials. Why is it "Phase IIa", instead of just "Phase II"? And, is there any info, at all, about this application for Targretin Gel? Thanks, Bob