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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?

To: Hippieslayer who wrote (26014)	10/6/1998 11:55:00 AM
From: celeryroot.com	Read Replies (1) \| Respond to of 32384

Fugazi.....as a matter of fact the number is gradually increasing. Aids patients are starting to have resistence to the current treatments and super strains are appearing.

To: Hippieslayer who wrote (26014)	10/7/1998 1:11:00 AM
From: Cheryl Galt	Read Replies (2) \| Respond to of 32384

RE: the number of current KS patients >> According to certain Dermatologist assoc, the # of KS patients is dwindling down rapidly due to PI therapy. Steve, I believe there's is considerable controversy over whether/why PI therapy fails. I think many contend that failure is often due -- NOT to the therapy itself, -- but to poor patient COMPLIANCE, either from patient laxity, the sheer difficulty of managing the timing of so many meds, -- or the patient's economic difficulty in obtaining the expensive drugs in sufficient and continuous supply. -------------------- Dwindling in some patient populations may be due to another reason: In Post # 22847 last June 30, a physician named D. Baer with an email address at UC SF had this to say: Re: "the decline [in KS] may be temporary as the number of patients failing PI's continues to increase..." The decline in KS began before the introduction of PI's and has more to do, in my opinion, with changed sexual practices in the gay community. KS, now shown to have a unique viral etiology, was confined almost exclusively to gay AIDS patients and was probably a sexually transmitted disease. I wouldn't count on a big turnaround in case numbers. Message 5058492 -------------------- DMB seems to be a lurker who posts infrequently, every few months. Maybe he's too busy to be a heavy presence on SI, but he has made some interesting posts, IMO. ------------------ It would be interesting to bounce this discussion off some medical people who currently treat AIDS patients -- such as Izzy on the AGPH thread. Or some phone calls to treatment centers. If/when I get time, I'll look into this. Maybe others could too, and we can compare notes. ------------------ Regards, Cheryl