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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Robert S. who wrote (7614)	10/31/1998 4:52:00 PM
From: Robert K.	Read Replies (1) \| Respond to of 17367

I guess that researcher has a right to their opinion. I dont go for the (role of endotoxin in doubt) theory of his. I do agree with his first statement though> >There is strong evidence to implicate endotoxin released from gram negative bacteria in the pathogenesis of the sepsis syndrome and related conditions< IMO Equally perplexing is the role of the bodys OWN NATURAL bpi in the sepsis syndrome..I ask, why is this so? Why their conclusion? > >Pediatr Infect Dis J 1995 Dec;14(12):1087-91 Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome. Wong HR, Doughty LA, Wedel N, White M, Nelson BJ, Havrilla N, Carcillo JA Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA. Bactericidal/permeability-increasing protein (BPI) is a neutrophil azurophilic granule component that is bactericidal towards Gram-negative bacteria and inhibits lipopolysaccharide-mediated inflammatory responses. We conducted a prospective study to measure plasma BPI concentrations in 36 critically ill children with and without the sepsis syndrome. Plasma BPI concentrations ranged from 0.5 to 452 ng/ml. Patients with the sepsis syndrome had higher median plasma BPI concentrations than critically ill controls (5.1 vs. 1.8 ng/ml, P = 0.006). Patients with organ system failure had higher median plasma BPI concentrations than those with no organ system failure (4.5 vs. 1.3 ng/ml, P = 0.001). Plasma BPI concentrations were positively associated with pediatric risk of mortality score (P = 0.03, rs = 0.4). These data provide the first clinical insights regarding the role of endogenous BPI production in critically ill children and suggest that BPI may play an important role in host defenses.

To: Robert S. who wrote (7614)	10/31/1998 6:13:00 PM
From: Cacaito	Read Replies (4) \| Respond to of 17367

Robert S, it is a review, not an original work, the bottom of the reference specify it. Your reference is a very good review. This is very important to sit down and learn. But, one will not get a new development from it. It is the difference between reviewing the work of Kenneth Starr or actually doing the investigation. Everybody has an opinion about it, but He did the work. Holzheimer refers to certain recent works against the evidence that suppressing endotoxins is not worth it, well that probably is referring to other failures we have review before (E5, antiTNF, Cento drug....), What does that has to do with BPI, did he included BPI "failures" as evidence, Not. I do not have the full printed version, I do not know what does he refer to. And, he proposed about the L-Forms, interesting but I could proposed that BPI will not give a chance for bacteria to form L-forms, they will be long dead before that, since BPI is so early in the killing that there is not chance for bacteria to activate other mechanisms, Not feasible, then prove it the other way. You are right in one sense, you are skeptical of a work in progress. But everybody here since to be too, that is why Xoma is 10% of my portfolio, I could not tolerate a bigger loss (I mean bet). Patience, in couple of month we will have the results.