To: Cacaito who wrote (7618 ) 11/1/1998 8:15:00 PM From: Robert S. Respond to of 17367
Cacaito, as is often the case, you have made some valid points but there are some statements from your last post that warrant comment:Robert S, it is a review, not an original work, the bottom of the reference specify it. While it may be a review and not an original work, the fact that it was published in a peer-reviewed medical journal suggests that at least some members of the medical community agree with the conclusions presented, and attest to the scientific accuracy and validity of the study. Granted, peer-review is not foolproof, but it does filter out those studies lacking in any of said criteria.Holzheimer refers to certain recent works against the evidence that suppressing endotoxins is not worth it, well that probably is referring to other failures we have review before (E5, antiTNF, Cento drug....), What does that has to do with BPI, did he included BPI "failures" as evidence, Not. I do not have the full printed version, I do not know what does he refer to. The review article was published in 1998 and I have to believe that a researcher in this field would be cognizant of BPI.Your reference is a very good review. This is very important to sit down and learn. But, one will not get a new development from it. It is the difference between reviewing the work of Kenneth Starr or actually doing the investigation. Everybody has an opinion about it, but He did the work. A peer-reviewed scientific review does have attributes (e.g., 20-20 hindsight, comparison to similar studies, a greater degree of objectivity) that an original research project lacks and, as you said, one can learn from it. Similarly, the fact that a published article pertains to original research, does not guarantee that the research adds to our collective knowledge. If we accept, as scientifically correct, your critique of the Lutsar study, then this illustrates that original research may very well lack some of the benefits of published reviews. In fact, was not your critique of the Lutsar study itself a review? And, did we not learn perhaps more from your comments and opinions than those who performed the actual investigation?