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Biotech / Medical : Pharmacyclics (PCYC) -- Ignore unavailable to you. Want to Upgrade?


To: Harold Engstrom who wrote (392)12/4/1998 5:43:00 PM
From: Biomaven  Read Replies (2) | Respond to of 717
 
Harold,

There is competition in the light-activated stuff: QLTIF and MRVT. The QLTIF entry (Photofrin) is on the market, but has had limited acceptance because of problems such as photosensitivity. The PCYC stuff definitely seems better than Photofrin - less photosensitivity and operates at a better wavelength that allows deeper penetration and use inside blood vessels. It's hard to find out much about the MRVT stuff - more glossy pictures than hard facts.

My own view is that the PDT therapy for cancer is very much a sideshow in the PCYC valuation model, although it garners nearly as much attention as does Gd-Tex.

There are various other attempted radiation-sensitizers wandering around. I have seen no evidence that any of them are anywhere near as good as Gd-Tex or as far along development-wise. Some don't work well in hypoxic cells and others are only preferentially taken up by dividing cells, so don't work in slow-growing tumors or have to be given for a long time.

I feel a little like a voice in the wilderness on this one, and could do with some more company <G>.

Peter