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Biotech / Medical : The Stock for 1999(Polymedica)PLMD(Medical Supply Co.) -- Ignore unavailable to you. Want to Upgrade?

To: Arthur Radley who wrote (2420)	1/20/1999 5:01:00 PM
From: Abuckatatime	Respond to of 3414

Beware of small blurbs. <What NEC has developed is a new urine test that can give accurate results in just 10 seconds.> Accurate for what purpose? The renal threshold for plasma glucose is in the range of 180-200 mg/DL. Glucose won't normally appear in the urine until that blood level is reached. Urine testing, using either currently available dipsticks, or the apparently more quantitative NEC variety, is of limited utility in monitoring blood glucose fluctuations in diabetics because of this physiologic limitation. I would also suspect that introduction of this product on the U.S. market, for whatever indication, would require FDA approval.(?) Blood yes, urine no for accurate glucose monitoring.

To: Arthur Radley who wrote (2420)	1/20/1999 6:23:00 PM
From: Abuckatatime	Read Replies (1) \| Respond to of 3414

Another drawback. A "real-time" problem exists when using urine samples to monitor glucose levels. Urine collects over hours in the bladder before being voided. A urine glucose measurement will give an indication of what the average blood glucose levels were during the interval between voidings. It does not indicate what the blood levels are at the moment. In type 1 individuals, especially those who are especially labile or who are attempting to maintain tight glucose control, obtaining accurate real-time measurements can be particularly important. The accuracy of urine testing can be improved via a double void procedure but still there is an inherent inaccuracy because of the delay between urine filtration in the kidneys and collection at the urethra. Placement of a catheter might enhance accuracy but I doubt many would choose this option.