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Biotech / Medical : Cistron Biotechnology(CIST)$.30 -- Ignore unavailable to you. Want to Upgrade?

To: Walter Morton who wrote (2004)	3/7/1999 2:15:00 AM
From: Walter Morton	Read Replies (1) \| Respond to of 2742

Much evidence implicates interleukin-1b (IL-1b ) in sleep regulation. Two previous studies indicated that levels of IL-1b mRNA were affected by sleep. In the current study, levels of IL-1b mRNA and IL-1 receptor accessory protein (IL-1RAP) mRNA were determined 1 h after the beginning of light and dark periods and after sleep deprivation, using the reverse transcriptase-polymerase chain reaction and mutated internal standards. Daytime samples contained relatively more IL-1b mRNA than nighttime samples and levels of IL-1b mRNA were higher after sleep deprivation. These changes occurred in the hypothalamus, hippocampus, cerebral cortex and the mesencephalon/pons. In contrast, IL-1 RAP mRNA level did not seem to be affected by sleep. vetmed.wsu.edu