To: technetium who wrote (103 ) 4/20/2022 8:14:51 PM From: technetium Read Replies (1) | Respond to of 267 This week was a continued case of may you live interesting times, and the word “Meh” As the war drags on so does the relatively lackluster performance. In general terms the week was a downer both in Biotech and the broader indices. (The NASDAQ composite was the winner in that it was down only 1.2% for the week.) The most notable individual stock was the “profit taking” in PHIO, which last week had zoomed into the YTD first place with a weekly gain of +168.9%). This week erased -49.4% from it’s value so now its YTD is only a respectable though not earth shaking +19%, dropping it to 13th place. For the contest portfolios, the week had no portfolio in the black, and brought a continued slide of -3.7% in the median portfolio, and the median YTD portfolio is now -26% in the red. In the top 10 portfolio list, in contrast to last week, there is a fair bit of reordering in the portfolio positions, except DIEGOSAN is still in the top spot, as well as being the only portfolio in the black (+1.4%). Congratulations to TAMBORELLI, breaking into the top 10 for the first time with this week’s top portfolio performance (a loss of only -0.1%), and a welcome back to A.J. MULLEN after a four week absence.Report Time Ranges From To Recent 4/8/22 4/15/22 YTD 12/31/21 Index Performance Symbol Recent YTD ^IXIC -2.63% -14.66% ^NBI -1.19% -10.62% ^SPSIBI -2.92% -21.63% Share Performance Recent YTD Top 5 Bottom 5 Top 5 Bottom 5 PTE 26.227% PHIO -49.362% MACK 58.82% PRQR -90.18% TRIB 24.414% BCYC -48.904% ALBO 56.93% MEIP -78.74% BBI 17.319% FULC -37.753% OPTN 56.79% VLON -77.59% GNCA 15.000% CYCC -27.562% FENC 40.91% AKBA -76.19% VSTM 13.462% MYOV -21.862% BLCM 35.57% TOMDF -75.52% Top 10 Portfolio Performance YTD DIEGOSAN 1.33% DEW DILIGENCE -5.03% BRENDAN_49 -6.97% TECHNETIUM -9.17% JACK HARTMANN -9.43% HORSEINALFALFA -13.40% STOICNORSKI -14.82% GENEGURU -17.47% TAMBORELLI -17.51% A.J. MULLEN -18.44% Average and Median Portfolio Performance Avg Recent Avg YTD Median Recent Median YTD -$4,053 -23.87% TWOONE1 -$3,212 RAJU_BIJLEE -26.03% -5.14% BRENDAN_49 -3.674%