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Biotech / Medical : PFE (Pfizer) How high will it go? -- Ignore unavailable to you. Want to Upgrade?

To: James Baker who wrote (3275)	6/5/1998 10:35:00 PM
From: Brander	Read Replies (1) \| Respond to of 9523

Off Topic Mr Baker, thank you for posting that data. Obviously, in gm + cocci that are resistant to penicillin, The Medical Letter first drug of choice (PCN) would not be appropriate. One would use one of the alternatives listed. If you are having trouble with the information that I posted, please read The Medical Letter issue that I cited and posted. I got the information directly from that issue. Thank You.

To: James Baker who wrote (3275)	6/5/1998 10:40:00 PM
From: Tunica Albuginea	Read Replies (2) \| Respond to of 9523

James Baker,Re: " Staph aureus resistance! The data for isolates of 650 S. aureus from patients in the Denver area was on my desk today. ONLY 10% are sensitive to PCN/AMP. 90% are resistant to these antibiotics. These are mainly outpatient cultures from real world patients! Jim " ======================================================= Jim, excellent work and thanks for your help. Full time teaching of medical students is not my primary line and frankly I was starting to tire out in the last couple of days. So the relief provided is greatly appreciated,gg. I will further chalk you into the camp of those that seek the facts, " and only the facts Jack ". Please keep us posted.... Again, I think that all physicians should read Dr J.Lynch's seminal work that I provided earlier on antibiotic resistance.It is truly frightening. It is also appalling that to me that Pfizer has chosen to spend money and time developing an antibiotic, " Trovan, that " kills everything". You and I ( and a few others ) unfortunately know only too well, that - a " gunshot " approach to treat infections is NEVER recommended by Infectious Disease specialists, ( IDs ) except for 1 or 2 days only, until the organism is identified , and a " sharp shooting" antibiotic can be provided . -that that increases the chance of infection with worse, more resistant, more virulent bacteria. -that it's widespread use ( when actively pushed by reps in Drs offices as a " do it all antibiotic "), will render it obsolete very rapidly through the rapid emergence of resistance. Finally, one reason more and more Americans are finding HMOs and Managed care revolting, is because they see in it exactly this mentality depicted recently of indiscriminately throwing pills and drugs at diseases, in a guess work type of fashion, devoid of any meaningful scientific attempt at accurately diagnosing first and following with similarly accurate treatment; " just take this pill "; " you don't need any tests ". This of course is totally different from what they've being taught in any good medical school. I'll get off the soapbox now, TA