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To: Skeeter Bug who wrote (215488)	8/13/2009 1:27:47 AM
From: Elroy Jetson	Read Replies (1) \| Respond to of 306849

Arachidonicphobia is the fear of Arachidonic acid, which is one of the essential fatty acids required by most mammals. If you knew about Arachidonic acid, you'd make sure you ate it every day. Arachidonic acid is a polyunsaturated fatty acid that is present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositides) of membranes of the body's cells, and is abundant in the brain and muscles. In addition to being involved in cellular signaling as a lipid second messenger involved in the regulation of signaling enzymes. Arachidonic acid is necessary for the repair and growth of skeletal muscle tissue. One of the lead researchers of the Baylor study on arachidonic acid, Mike Roberts MS, CSCS, has authored an article published under the title Arachidonic Acid, The New Mass Builder explaining the role of this nutrient in muscle anabolism, and its potential for the enhancement of muscle size and strength. The concept of the "no pain, no gain" paradigm is simple: a training stimulus that does not elicit localized inflammation and soreness will not yield optimal muscle growth. So, what about arachidonic acid's role in muscle inflammation? Well for starters, arachidonic acid (AA, 20:4n-6) is an essential Omega-6 (1-6) polyunsaturated fatty acid that is abundant in skeletal muscle membrane phospholipids (figure 2). It is also the body's principle building block for the production of prostaglandins, which are known to have various physiological roles including a close involvement in inflammation. Furthermore, recent evidence suggests that the prostaglandin isomer PGF2a has a potent ability to stimulate muscle growth. As such, arachidonic acid is a regulator of localized muscle inflammation, and may be a central nutrient controlling the intensity of the anabolic/tissue-rebuilding response to weight training." Arachidonic acid is one of the most abundant fatty acids in the brain, and is present in similar quantities to DHA (docosahexaenoic acid). The two account for approximately 20% of its fatty acid content[8]. Like DHA, neurological health is reliant upon sufficient levels of arachidonic acid. Among other things, arachidonic acid helps to maintain hippocampal cell membrane fluidity[9]. It also helps protect the brain from oxidative stress by activating perioxisomal proliferator-activated receptor-y[10]. ARA also activates syntaxin-3 (STX-3), a protein involved in the growth and repair of neurons[11]. Arachidonic acid is also involved in early neurological development. In one study funded by the U.S. National Institute of Child Health and Human Development, infants (18 months) given supplemental arachidonic acid for 17 weeks demonstrated significant improvements in intelligence, as measured by the Mental Development Index (MDI)[12]. This effect is further enhanced by the simultaneous supplementation of DHA and ARA. Arachidonic acid, it's as terrifying as cholesterol and other basic nutrional building blocks in your body. .

To: Skeeter Bug who wrote (215488)	8/13/2009 1:32:55 AM
From: Elroy Jetson	Read Replies (1) \| Respond to of 306849

Under normal metabolic conditions, the increased consumption of arachidonic acid is unlikely to increase inflammation. ARA is metabolized to both pro-inflammatory and anti-inflammatory molecules. Studies giving between 840 mg and 2,000 mg per day to healthy individuals for up to 50 days have shown no increases in inflammation or related metabolic activities. Increased arachidonic acid levels are actually associated with reduced pro-inflammatory IL-6 and IL-1 levels, and increased anti-inflammatory tumor-necrosis factor-beta[19]. This may reduce inflammation under certain conditions. Arachidonic acid does still play a central role in inflammation related to many diseased states. How it is metabolized in the body dictates its inflammatory or anti-inflammatory activity. Individuals suffering from joint pains or active inflammatory disease may find that increased arachidonic acid consumption exacerbates symptoms, probably because it is being more readily converted to inflammatory compounds. Likewise, high arachidonic acid consumption is not advised for individuals with a history of inflammatory disease, or that are in compromised health. It is also of note that while ARA supplementation does not appear to have pro-inflammatory effects in healthy individuals, it may counter the anti-inflammatory effects of omega-3 EFA supplementation. Arachidonic acid supplementation in daily dosages of 1,000-1,500 mg for 50 days has been well tolerated during several clinical studies, with no significant side effects reported. All common markers of health including kidney and liver function, serum lipids, immunity, and platelet aggregation appear to be unaffected with this level and duration of use. Furthermore, higher concentrations of ARA in muscle tissue may be correlated with improved insulin sensitivity. Arachidonic acid supplementation by healthy adults appears to offer no toxicity or significant safety risk. The safety of arachidonic acid supplementation in patients suffering from inflammatory or other diseased states is unknown, and is not recommended. .

To: Skeeter Bug who wrote (215488)	8/13/2009 2:47:32 AM
From: damainman	Read Replies (1) \| Respond to of 306849

"The data also shows that the best drug against heart attacks is aspirin - and anti-inflammatory with zero impact on cholesterol. for those with logical abilities, there is a clue as to a significant root cause of heart disease." Aspirin is used to prevent strokes/heart attack not for its anti inflammatory activity but because it inhibits platelet aggregation. Caffeine also has anti platelet activity of which benefit to whom I do not know.

To: Skeeter Bug who wrote (215488)	8/13/2009 3:03:39 AM
From: kikogrey	Read Replies (2) \| Respond to of 306849

Well here's another anecdote. My 93 1/2 year old mother (no cancer, heart disease, diabetes, dementia ) hates fruits and vegetables eats only processed food never met a trans fat she didn't like half of her grocery list is twinkie -like foods (cheesecake, candy, Little Debbie) refuses to eat ANY food from Trader Joes most lifelong pessimistic attitude on record no social or other interests at all (lifelong) Not that I would ever recommend this diet (or life attitude) and I realize an anecdote doesn't mean it's so--it does illustrate that there's other factors in longevity/lack of disease than diet.