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Biotech / Medical : SGNC Sanguine Corp. Info Thread -- Ignore unavailable to you. Want to Upgrade?

To: R>G> who wrote (78)	7/9/1998 1:37:00 AM
From: chirodoc	Respond to of 100

pfc's IMPROVE lung function in animals and don't gloss over this sentence: " The procedure was tolerated well by the animals." ...phase I, II trials here we come! J Formos Med Assoc 1998 Jun;97(6):392-399 Liquid ventilation for treatment of meconium aspiration syndrome in a piglet model. Kuo CY, Hsueh C, Wang CR Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan. [Medline record in process] We tested the hypothesis that liquid ventilation (LV) with perfluorocarbon (PFC) can remove aspirated meconium and improve lung function in experimental meconium aspiration syndrome (MAS). PFC (FC-77) was used as the medium in LV. Sixteen piglets were divided into control and LV groups (8 animals/group). All animals received slurry meconium (20% in normal saline) via endotracheal instillation at baseline. Thirty minutes later, the LV group received 15 cycles of LV. Pulmonary mechanics, arterial blood gases, and hemodynamic values were recorded at baseline, and 30, 60, 120, 180, and 240 minutes after meconium instillation. Chest radiographs and lung sections were taken and scored at the end of the study. The percentage of meconium cleared by LV was calculated as the ratio of the dry weight of washings to that of meconium instilled, multiplied by 100. The procedure was tolerated well by the animals. LV cleared 25% +/- 7% of the instilled meconium. Tidal volume (9.5 +/- 2.0 vs 7.1 +/- 0.8 mL/kg, p = 0.012), respiratory system compliance (2.32 +/- 0.60 vs 1.60 +/- 0.24 mL/cmH2O, p = 0.01), PaO2 (65 +/- 7 torr vs 55 +/- 6 torr, p = 0.0067), and arterial to alveolar oxygen ratio (0.14 +/- 0.01 vs 0.12 +/- 0.01, p = 0.0077) were improved in the LV group at 60 minutes after meconium instillation compared with those of the control group. The scores of exudative debris (1.7 +/- 0.3 vs 2.1 +/- 0.2) and visible meconium (1.4 +/- 0.5 vs 2.1 +/- 0.5) were significantly lower in the LV group. In conclusion, short-term L.V with FC-77 can partially remove aspirated meconium from the lungs and improve pulmonary function transiently.

To: R>G> who wrote (78)	7/11/1998 1:33:00 PM
From: R>G>	Read Replies (4) \| Respond to of 100

Here's some brought over from the other thread. General Information on Blood, Blood Substitutes, and Perfluorocarbons. Message 4750366 Message 4750411 Message 4750435 Message 4784580 Message 4831007 Message 4834748 Message 4837401 Message 4846921 Message 4847575 Message 4855072 Message 4862280 Message 4862816 Message 4862822 Message 4862825 Message 4864192 Message 4878744 Message 4926945 Message 4927082 Message 4943515 Message 4943563 Message 4981827 Message 4984036 Message 4989334 Message 4989802 Message 4990969 Message 5100338 Message 5100367 Message 5100367 Message 5100338 Message 5127581